nalysis of non-coding RNAs transcribed from ultraconserved regions in digestive tract cancer and its diagnostic and therapeutic application

消化道癌超保守区转录非编码RNA分析及其诊断和治疗应用

• 批准号: 24659163
• 负责人: YASUI Wataru
• 金额: $ 2.5万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659163/
• 关键词: ncRNA; 超保存領域（T-UCR); 消化管癌; 診断・治療展開; 発現制御; メチル化; 非翻訳RNA; 超保存領域（T-UCR）

Transcribed ultraconserved region (T-UCR) transcripts are a novel class of long non-coding RNAs transcribed from ultraconserved regions (UCRs). The expression analysis of T-UCR in digestive tract cancers demonstrated that, in gastric cancer, most of T-UCRs including UCR118+A and 158+A were down-regulated by methylation, whereas UCR416+A and 420+A were overexpressed. Down-regulation of miR-148 and miR-143/-145 participated in cancer invasion and morphogenesis with interaction with stromal cells and served as prognostic factor of gastric cancer patients.

转录的超保守区（T-UCR）转录物是一类新的由超保守区（UCR）转录的长链非编码RNA。T-UCR在消化道肿瘤中的表达分析表明，在胃癌中，包括UCR 118 +A和158+A在内的大多数T-UCR因甲基化而下调，而UCR 416 +A和420+A则过表达。miR-148和miR-143/-145的下调通过与基质细胞的相互作用参与胃癌的侵袭和形态发生，并作为胃癌患者的预后因子。

项目成果

Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-a secretion in gastric cancer

由 SEC11A 编码的信号肽酶复合物 18 通过 TGF-a 分泌促进胃癌进展

• 期刊: Oncogene
• 影响因子: 8
• 作者: Oue N;Naito Y;Hayashi T;Takigahira M;Kawano-Nagatsuma A;Sentani K;Sakamoto N;Zarni Oo H;Uraoka N;Yanagihara K;Ochiai A;Sasaki H;Yasi W
• 通讯作者: Yasi W

Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer

• DOI: 10.1002/ijc.27735
• 发表时间: 2013-02-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Shinagawa, Kei;Kitadai, Yasuhiko;Chayama, Kazuaki
• 通讯作者: Chayama, Kazuaki

Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis

• DOI: 10.1093/carcin/bgs121
• 发表时间: 2012-05-01
• 期刊: CARCINOGENESIS
• 影响因子: 4.7
• 作者: Sentani, Kazuhiro;Oue, Naohide;Yasui, Wataru
• 通讯作者: Yasui, Wataru

Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice

Claudin-18 缺乏会导致小鼠细胞旁 H 渗漏、白细胞介素 1β 上调和萎缩性胃炎

• 发表时间: 2011
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Travis WD;et al;Hayashi D
• 通讯作者: Hayashi D

HP and carcinogenesis -Pathogenesis and novel diagnostic and therapeutic targets

HP 和癌变 - 发病机制和新的诊断和治疗靶点

• 发表时间: 2013
• 作者: Sakamoto N;Naito Y;Oue N;Sentani K;Uraoka N;Oo HZ;Yanagihara K;Aoyagi K;Sasaki H and Yasui W;Yasui W
• 通讯作者: Yasui W