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Development a novel therapy targeting NETs formation for anti-neutrophil cytoplasmic antibody-associated vasculitis

Development a novel therapy targeting NETs formation for anti-neutrophil cytoplasmic antibody-associated vasculitis
开发针对抗中性粒细胞胞质抗体相关性血管炎的 NET 形成的新疗法
批准号：
24659472
负责人：
HARIGAI Masayoshi
金额：
$2.33万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659472/
关键词：
膠原病学抗好中球細胞質抗体関連血管炎関節リウマチNETS形成シトルリン化自然免疫

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中文摘要
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英文摘要
Objective: We investigated involvement of neutrophil extracellular traps (NETs) formation in pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and tried to develop a murine model of systemic vasculitis. Methods: We separated neutrophils from peripheral blood using a magnet beads-based negative selection method. Immunoglobulin G (IgG) fraction of Myeloperoxidase (MPO)-ANCA positive serum was prepared using Protein A column. A murine model of systemic vasculitis was explored using Candida albicans water-soluble fraction (CAWS) and house-made rabbit anti-mouse MPO polyclonal antibody. Results. IgG fraction of MPO-ANCA positive serum induced NETs formation in the presence of recombinant C5a. CAWS and house-made rabbit anti-mouse MPO polyclonal antibody could not induce systemic vasculitis in C57BL6 mice. We measured panel of cytokines and chemokines in sera from patients with ANCA-associated vasculitis. All cytokines and chemokines were measurable in them.
期刊论文(10)
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会议论文
High Clinical Remission Rate With Relatively High Incidence Of Serious Infection In Newly-Onset ANCA - Associated Vasculitides In Japan - A Report From The Nationwide Prospective Cohort Study
日本新发 ANCA 相关血管炎的临床缓解率较高，严重感染发生率相对较高 - 来自全国前瞻性队列研究的报告
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Harigai Masayoshi, et al.]
通讯作者： et al.
抗好中球細胞質抗体関連血管炎・急速進行性糸球体腎炎の寛解導入治療の現状とその有効性と安全性に関する観察研究(RemIT-JAV-RPGN)
抗中性粒细胞胞浆抗体相关性血管炎/急进性肾小球肾炎缓解诱导治疗现状及其疗效和安全性观察研究（RemIT-JAV-RPGN）
DOI： --
发表时间： 2013
期刊： 日本臨床「血管炎」増刊号
影响因子： --
作者： [針谷正祥, 山縣邦弘, 本間栄, 臼井丈一, 土橋浩章, 佐田憲英]
通讯作者： 佐田憲英
免疫・アレルギー疾患イラストレイテッド
免疫学/过敏性疾病图解
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [平原潔, 中山俊憲]
通讯作者： 中山俊憲
Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study.
DOI： 10.1186/ar4550
发表时间： 2014-04-23
期刊： Arthritis research & therapy
影响因子： 4.9
作者： [Sada KE, Yamamura M, Harigai M, Fujii T, Dobashi H, Takasaki Y, Ito S, Yamada H, Wada T, Hirahashi J, Arimura Y, Makino H, Research Committee on Intractable Vasculitides, the Ministry of Health, Labour and Welfare of Japan]
通讯作者： Research Committee on Intractable Vasculitides, the Ministry of Health, Labour and Welfare of Japan
共 8 条
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    • 批准号：
      20390158
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.82万
    • 财政年份：
      2008
    • 负责人：
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    • 依托单位：
      Tokyo Medical and Dental University
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    • 批准号：
      16390286
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.15万
    • 财政年份：
      2004
    • 负责人：
      HARIGAI Masayoshi
    • 依托单位：
      Tokyo Medical and Dental University
    APPLICATION OF TRISTETRAPROLIN TO GENE THERAPY FOR RHEUMATOID ARTHRITIS
    • 批准号：
      12670440
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $1.34万
    • 财政年份：
      2000
    • 负责人：
      HARIGAI Masayoshi
    • 依托单位：
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    海外基金