The development of molecular imaging based on the novel artificial virus and the application to the individual therapy for pancreatic cancer

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We investigated the expression profiles in the pancreatic cancer, colon cancer, gastric cancer, and esophageal cancer using cultured cell lines and resected samples in the surgical operation. We found the several molecules, which are related with the invasion and metastasis of cancer cells. We also investigated the expression profiles of cancer-related fibroblasts and found the specific molecule, which is related with clinicopathological factors. We also performed the in vitroand in vivo analyses and then found its functional roles in the cancer progression. We also developed the novel DDS using the artificial virus, which can target the specific cells and include the specific drug, which are involved in the function of cancer cell or cancer-related fibroblasts. In the next study, we will develop the individual t herapy based on our DDS system.