The development of molecular imaging based on the novel artificial virus and the application to the individual therapy for pancreatic cancer

基于新型人工病毒的分子影像学进展及其在胰腺癌个体化治疗中的应用

• 批准号: 24659613
• 负责人: OHUCHIDA Kenoki
• 金额: $ 2.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659613/
• 关键词: 膵癌; DDS; 人工ウイルス; 癌

We investigated the expression profiles in the pancreatic cancer, colon cancer, gastric cancer, and esophageal cancer using cultured cell lines and resected samples in the surgical operation. We found the several molecules, which are related with the invasion and metastasis of cancer cells. We also investigated the expression profiles of cancer-related fibroblasts and found the specific molecule, which is related with clinicopathological factors. We also performed the in vitroand in vivo analyses and then found its functional roles in the cancer progression. We also developed the novel DDS using the artificial virus, which can target the specific cells and include the specific drug, which are involved in the function of cancer cell or cancer-related fibroblasts. In the next study, we will develop the individual t herapy based on our DDS system.

我们使用培养的细胞系研究了胰腺癌，结肠癌，胃癌和食管癌的表达谱，并在手术手术中切除样品。我们发现了几个与癌细胞的侵袭和转移有关的分子。我们还研究了与癌症相关的成纤维细胞的表达谱，并发现了与临床病理学因素有关的特定分子。我们还进行了体外分析，然后在癌症进展中发现了其功能作用。我们还使用人工病毒开发了新型的DD，该病毒可以针对特定细胞，并包括与癌细胞或与癌症相关的成纤维细胞功能有关的特定药物。在下一项研究中，我们将基于DDS系统开发单独的Herapy。

项目成果

Fibroblasts Expression podoplanin Enhance the Tumor Progression of Invasive Ductal Carcinoma of Pancreas

成纤维细胞表达足平蛋白促进胰腺浸润性导管癌的肿瘤进展

• 发表时间: 2012
• 作者: Shindo K;Aishima S;Ikenaga N;Ohuchida K;Mizumoto K;Tanaka M;Oda Y
• 通讯作者: Oda Y

Inhibits Pancreatic Stellate Cells and Tumor-Stromal Interaction in Pancreatic Cancer

抑制胰腺癌中的胰腺星状细胞和肿瘤间质相互作用

• 发表时间: 2012
• 作者: Kozono S;Ohuchida K;Eguchi D;Fujiwara K;Zhao M;Cui L;Mizumoto K;Tanaka MAntifibrotic Agent;Pirfenidone
• 通讯作者: Pirfenidone

膵癌の遠隔転移に関与する新規遺伝子 MAL2(myelin and lymphocyte protein2)の同定

鉴定参与胰腺癌远处转移的新基因MAL2（髓磷脂和淋巴细胞蛋白2）

• 发表时间: 2013
• 作者: 江口大樹;大内田研宙;小薗真吾;崔林;藤原謙次;趙茗;赤川進;寅田信博;Cases Ana Ines;大塚隆生;上田純二;高畑俊一;水元一博;田中雅夫
• 通讯作者: 田中雅夫

CD166 陰性膵癌細胞は強い浸潤能・遊走能を有する

CD166阴性胰腺癌细胞具有较强的侵袭和迁移能力

• 发表时间: 2013
• 作者: 藤原謙次;大内田研宙;進藤幸治;赤川進;江口大樹;小薗真吾;崔林;大塚隆生;高畑俊一;相島慎一;水元一博;田中雅夫
• 通讯作者: 田中雅夫

Pamcreatic Cancer Cells in Hypoxia Enhance the Motility of Pancreatic Stellate Cells Via Increased Secretion of Vascular Endothelial Growth Factor

缺氧状态下的胰腺癌细胞通过增加血管内皮生长因子的分泌来增强胰腺星状细胞的运动性

• 发表时间: 2012
• 作者: Eguchi D;Ohuchida K;Kozono S;Cui L;Zhao M;Fujiwara K;Akagawa S;Otsuka T;Takahata S;Mizumoto K;Tanaka M
• 通讯作者: Tanaka M