The improvement of drug delivery based on the normalization of cancer stroma and its application for the treatment of pancreatic cancer

基于癌基质正常化的药物递送改进及其在胰腺癌治疗中的应用

• 批准号: 25670584
• 负责人: OHUCHIDA Kenoki
• 金额: $ 2.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670584/
• 关键词: 膵がん; 膵星細胞; 細胞外基質; 膵癌; 癌間質相互作用; 癌浸潤

In the present study, we focused on tumor-related stroma and its remodeling and normalization and mainly investigated the mechanism of cancer-stromal interaction between cancer cells and pancreatic stellate cells. Then, we identified the several molecules, which are related with the extracellular matrices derived from pancreatic stellate cells and found that such matrices affect the invasion and migration of pancreatic cancer cells. These data suggest that the remodeling of cancer stroma by normalization based on the novel molecules may lead to the development of new therapy for pancreatic cancer.

在本研究中，我们重点关注肿瘤相关基质及其重塑和正常化，主要研究癌细胞和胰腺星状细胞之间的癌症-基质相互作用机制。然后，我们鉴定了与胰腺星状细胞来源的细胞外基质相关的几种分子，发现这些基质影响胰腺癌细胞的侵袭和迁移。这些数据表明，通过基于新分子的正常化来重塑癌症间质可能会导致胰腺癌新疗法的发展。

项目成果

Pirfenidone inhibits desmoplasia of pancreatic cancer by regulating stellate cells

吡非尼酮通过调节星状细胞抑制胰腺癌结缔组织增生

• 发表时间: 2013
• 期刊: Cancer Research
• 影响因子: 11.2
• 作者: Shingo Kozono;Kenoki Ohuchida;Daiki Eguchi;Naoki Ikenaga;Kenji Fujiwara;Ming Zhao;Lin Cui;Koji Shindo;Kazuhiro Mizumoto;and Masao Tanaka
• 通讯作者: and Masao Tanaka

Tissue tablet method: an efficient tissue banking procedure applicable to both molecular analysis and frozen tissue microarray

组织片法：一种适用于分子分析和冷冻组织微阵列的高效组织库程序

• DOI: 10.1016/j.humpath.2013.08.013
• 发表时间: 2014
• 期刊: Hum Pathol
• 影响因子: 3.3
• 作者: Torata N;Ohuchida K;Akagawa S;Cui L;Kozono S;Mizumoto K;Aishima S;Oda Y;Tanaka M
• 通讯作者: Tanaka M

腫瘍内 heterogeneityに着目した膵癌個別化治療の可能性

关注肿瘤内异质性的胰腺癌个性化治疗的可能性

• 发表时间: 2013
• 期刊: 腫瘍個別化から細胞個別化へ.胆と膵
• 作者: Shindo Koji;Aishima Shinichi;Ohuchida Kenoki;Fujiwara Kenji;Mizumoto Kazuhiro;Tanaka Masao;Oda Yoshinao;大内田研宙大塚隆生水元一博田中雅夫
• 通讯作者: 大内田研宙大塚隆生水元一博田中雅夫

Kindlin-2 Expression in Peritumoral Stroma Is Associated With Poor Prognosis in Pancreatic Ductal Adenocarcinoma

• DOI: 10.1097/mpa.0b013e318279bd66
• 发表时间: 2013-05-01
• 期刊: PANCREAS
• 影响因子: 2.9
• 作者: Mahawithitwong, Prawej;Ohuchida, Kenoki;Tanaka, Masao
• 通讯作者: Tanaka, Masao

特集タイトル : 臨床検体から導き出す消化器病研究テーマ

专题标题：源自临床标本的胃肠疾病研究主题

• 发表时间: 2014
• 期刊: 6)膵液中バイオマーカーで膵疾患の診断、早期発見はできるか分子消化器病
• 作者: 大内田研宙;大塚隆生;水元一博;田中雅夫
• 通讯作者: 田中雅夫