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The improvement of drug delivery based on the normalization of cancer stroma and its application for the treatment of pancreatic cancer

The improvement of drug delivery based on the normalization of cancer stroma and its application for the treatment of pancreatic cancer
基于癌基质正常化的药物递送改进及其在胰腺癌治疗中的应用
批准号：
25670584
负责人：
OHUCHIDA Kenoki
金额：
$2.41万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2013
资助国家：
日本
项目状态：
已结题
起止时间：
2013-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670584/
关键词：
膵がん膵星細胞細胞外基質膵癌癌間質相互作用癌浸潤

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中文摘要
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英文摘要
In the present study, we focused on tumor-related stroma and its remodeling and normalization and mainly investigated the mechanism of cancer-stromal interaction between cancer cells and pancreatic stellate cells. Then, we identified the several molecules, which are related with the extracellular matrices derived from pancreatic stellate cells and found that such matrices affect the invasion and migration of pancreatic cancer cells. These data suggest that the remodeling of cancer stroma by normalization based on the novel molecules may lead to the development of new therapy for pancreatic cancer.
期刊论文(46)
专著(0)
科研奖励(0)
会议论文
Pirfenidone inhibits desmoplasia of pancreatic cancer by regulating stellate cells
吡非尼酮通过调节星状细胞抑制胰腺癌结缔组织增生
DOI： --
发表时间： 2013
期刊： Cancer Research
影响因子： 11.2
作者： [Shingo Kozono, Kenoki Ohuchida, Daiki Eguchi, Naoki Ikenaga, Kenji Fujiwara, Ming Zhao, Lin Cui, Koji Shindo, Kazuhiro Mizumoto, and Masao Tanaka]
通讯作者： and Masao Tanaka
Tissue tablet method: an efficient tissue banking procedure applicable to both molecular analysis and frozen tissue microarray
组织片法：一种适用于分子分析和冷冻组织微阵列的高效组织库程序
DOI： 10.1016/j.humpath.2013.08.013
发表时间： 2014
期刊： Hum Pathol
影响因子： 3.3
作者： [Torata N, Ohuchida K, Akagawa S, Cui L, Kozono S, Mizumoto K, Aishima S, Oda Y, Tanaka M]
通讯作者： Tanaka M
腫瘍内 heterogeneityに着目した膵癌個別化治療の可能性
关注肿瘤内异质性的胰腺癌个性化治疗的可能性
DOI： --
发表时间： 2013
期刊： 腫瘍個別化から細胞個別化へ.胆と膵
影响因子： --
作者： [Shindo Koji, Aishima Shinichi, Ohuchida Kenoki, Fujiwara Kenji, Mizumoto Kazuhiro, Tanaka Masao, Oda Yoshinao, 大内田研宙大塚隆生水元一博田中雅夫]
通讯作者： 大内田研宙大塚隆生水元一博田中雅夫
Kindlin-2 Expression in Peritumoral Stroma Is Associated With Poor Prognosis in Pancreatic Ductal Adenocarcinoma
DOI： 10.1097/mpa.0b013e318279bd66
发表时间： 2013-05-01
期刊： PANCREAS
影响因子： 2.9
作者： [Mahawithitwong, Prawej, Ohuchida, Kenoki, Tanaka, Masao]
通讯作者： Tanaka, Masao
共 18 条
    Elucidation of diversity and novel roles of APCs in the cancer microenvironment by scRNAseq with spatial gene expression analysis
    • 批准号：
      21K19530
    • 项目类别：
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额：
      $4.16万
    • 财政年份：
      2021
    • 负责人：
      OHUCHIDA Kenoki
    • 依托单位：
      Kyushu University
    Analysis of single-cell transcriptome with Drop-seq for heterogeneity in the tumor microenvironment derived from digestive cancers.
    • 批准号：
      19K22664
    • 项目类别：
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额：
      $4.16万
    • 财政年份：
      2019
    • 负责人：
      OHUCHIDA Kenoki
    • 依托单位：
      Kyushu University
    Elucidation of leading PSC induced basement membrane destruction mechanism and development of the regulating method by using pancreatic organoids
    • 批准号：
      17H04284
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.9万
    • 财政年份：
      2017
    • 负责人：
      OHUCHIDA Kenoki
    • 依托单位：
      Kyushu University
    Control of microenvironment involved in pancreatic cancer progression and defense by phenotype switching
    • 批准号：
      17K19602
    • 项目类别：
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额：
      $4.16万
    • 财政年份：
      2017
    • 负责人：
      OHUCHIDA Kenoki
    • 依托单位：
      Kyushu University
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