The development of therapy of pancreatic cancer stem cells and the surrounding stromal cells.

在本研究中，我们研究了胰腺癌干细胞及其周围的间质细胞，发现CD10阳性的间质细胞在胰腺癌进展过程中的癌细胞-间质相互作用中起着重要的作用。我们还探讨了CD10阳性细胞促进胰腺癌细胞侵袭的机制，发现MMP3参与了这一机制。这些数据表明，胰腺星状细胞之间存在异质性，这些细胞中的一个特定亚群在癌症进展中起着更重要的作用。

In the present study, we investigated the pancreatic cancer stem cells and the surrounding stromal cells and found that a specific cell population of stromal cells, CD10 positive pancreatic stellate cells, have an important role in the cancer-stromal interaction during pancreatic cancer progression. We also investigated the mechanisms of the promoting effects of CD10 positive cells on the enhancement of invasion of pancreatic cancer cells, and found that MMP3 is implicated in this mechanism. These data suggest that there is heterogeneity among pancreatic stellate cells and a specific subpopulation of these cells has more important role in cancer progression.