Early tendon-bone healing in anterior cruciate ligament reconstruction

前交叉韧带重建中的早期腱骨愈合

• 批准号: 24659676
• 负责人: KUROSAKA Masahiro
• 金额: $ 2.41万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659676/
• 关键词: 前十字靭帯; Statin; 再生医療; スタチン

The aim of this study was to test the hypothesis that enhanced angiogenesis and osteogenesis by locally applied simvastatin promotes tendon-bone healing after ACL reconstruction. Rabbits received ACL reconstruction with hamstring tendon graft and were implanted with either simvastatin-conjugated gelatin hydrogel or gelatin hydrogel alone in their bone tunnels. Histological and radiological analysis at week 2 demonstrated early tendon-bone healing with enhanced angiogenesis and osteogenesis in the simvastatin-treated group. Biomechanical testing at week 2 also demonstrated a significant increase in ultimate failure load in the simvastatin-treated group. This study suggested that local administration of low-dose simvastatin-conjugated gelatin hydrogel promotes the tendon-bone healing via its effect on both angiogenesis and osteogenesis at an early phase in a rabbit model, but does not affect biomechanical property in long-term after ACL reconstruction.

本研究的目的是验证局部应用辛伐他汀促进ACL重建后肌腱-骨愈合的血管生成和骨生成的假设。兔采用腘绳肌腱重建前交叉韧带，骨隧道内分别植入辛伐他汀结合明胶水凝胶或单独植入明胶水凝胶。第2周的组织学和放射学分析显示，辛伐他汀治疗组肌腱-骨早期愈合，血管生成和成骨增强。第2周的生物力学测试也显示辛伐他汀治疗组的最终衰竭负荷显著增加。本研究表明，局部给予低剂量辛伐他汀结合明胶水凝胶通过其对兔模型早期血管生成和成骨的影响来促进肌腱-骨愈合，但在ACL重建后长期不影响生物力学性能。

项目成果

Simvastatin局所徐放による前十字靭帯再建術後の移植腱-骨孔間の成熟促進効果について

辛伐他汀局部缓释对促进前交叉韧带重建后移植肌腱与骨孔成熟的影响

• 发表时间: 2012
• 作者: 岡真也;松本知之;久保晴司;松下雄彦;佐々木宏;西澤勇一郎;松崎時夫;斉藤高志;田畑泰彦;黒坂昌弘;黒田良祐
• 通讯作者: 黒田良祐

simvastatin局所徐放による前十字靭帯再建術後の移植腱-骨孔間の成熟促進効果について．

辛伐他汀局部缓释对促进前交叉韧带重建后移植肌腱与骨孔成熟的影响

• 发表时间: 2012
• 作者: Gao F;Kishida T;Ejima A;Gojo S;Mazda O.;岡真也，松本知之，久保晴司，松下雄彦，佐々木宏，西澤勇一郎，松崎時夫，斉藤高志，田畑泰彦，黒坂昌弘
• 通讯作者: 岡真也，松本知之，久保晴司，松下雄彦，佐々木宏，西澤勇一郎，松崎時夫，斉藤高志，田畑泰彦，黒坂昌弘