The relation between chronic inflammatory reaction and photoreceptor cell death in retinitis pigmentosa

我们证明了在rd10小鼠视网膜变性过程中，促炎细胞因子和趋化因子的表达增加、小胶质细胞的激活和光感受器的凋亡等一系列事件。此外，用n -乙酰半胱氨酸进行抗氧化处理可防止光感受器细胞死亡，同时抑制炎症因子和小胶质细胞活化。持续的慢性炎症反应可能有助于rd10小鼠视网膜变性的发病机制，建议使用抗氧化剂干预眼部炎症反应作为RP患者的潜在治疗方法。

We demonstrated sequential events involving increased expression of proinflammatory cytokines and chemokines, activation of microglia, and photoreceptor apoptosis during retinal degeneration of rd10 mice. Furthermore, antioxidant treatment with N-acetylcysteine prevented the photoreceptor cell death along with suppression of inflammatory factors and microglial activation. Sustained chronic inflammatory reaction may contribute to the pathogenesis of retinal degeneration in rd10 mice, suggesting interventions for ocular inflammatory reaction using antioxidants as a potential treatment for patients with RP.