The analysis of the macular blood flow in patients with retinitis pigmentosa

色素性视网膜炎患者黄斑血流分析

• 批准号: 24659764
• 负责人: ISHIBASHI Tatsuro
• 金额: $ 2.16万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659764/
• 关键词: 網膜色素変性; レーザースペックルフローグラフィー; 黄斑部網脈絡膜循環; 黄斑部感度; ウノプロストン点眼液; 黄斑部循環; 視細胞保護; 臨床

In the present study, we investigated the macular blood flow using laser speckle flowgraphy (LSFG) in patients with retinitis pigmentosa (RP) and its correlation with visual function. Our data showed that macular blood flow was decreased to approximately 60% in RP patients compared with control subjects. Moreover, the decreased macular blood flow was associated with the reduction of macular visual sensitivity in RP patients.We demonstrated topical unoprostone isopropyl might have a therapeutic efficacy, such as improvements of the macular sensitivity, in patients with RP. Surprisingly, the macular sensitivity was maintained not only in the treated eyes, but also in the fellow eyes. The change ratios of macular blood flow obtained from RP patient were significantly increased in both the treated and the fellow eyes. These results demonstrate that topical unoprostone might have a therapeutic efficacy as a consequence of the macular blood flow improvement.

本研究应用激光散斑血流图（LSFG）检测视网膜色素变性（RP）患者黄斑血流，并探讨其与视功能的关系。我们的数据显示，黄斑血流减少到约60%，RP患者与对照组相比。此外，黄斑血流减少与RP患者的黄斑视觉敏感度降低有关。我们证明，外用乌诺前列酮异丙酯可能对RP患者具有治疗效果，例如改善黄斑敏感度。 令人惊讶的是，不仅在治疗的眼睛中，而且在对侧眼睛中也保持了黄斑敏感性。RP患者黄斑血流变化率在治疗眼和对侧眼均明显增加。 这些结果表明，局部乌诺前列酮可能具有作为黄斑血流改善的结果的治疗功效。

项目成果

Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa

• DOI: 10.1111/aos.12293
• 发表时间: 2014-05-01
• 期刊: ACTA OPHTHALMOLOGICA
• 影响因子: 3.4
• 作者: Akiyama, Masato;Ikeda, Yasuhiro;Ishibashi, Tatsuro
• 通讯作者: Ishibashi, Tatsuro

網膜色素変性の病態解明と神経保護

色素性视网膜炎病理学的阐明和神经保护

• 发表时间: 2013
• 作者: Sasaki S;Miyazaki D;et al;池田康博
• 通讯作者: 池田康博

ウノプロストン点眼による網膜色素変性患者の網膜血流量変化

乌诺前列酮滴眼液对色素性视网膜炎患者视网膜血流的影响

• 发表时间: 2012
• 作者: 村上祐介;池田康博;秋山雅人;吉田倫子;鍋島崇寛;納富昭司;久冨智朗; 江内田寛;石橋達朗
• 通讯作者: 石橋達朗