CELLULAR REACTION AROUND THE INTRAOCULAR LENSES

人工晶状体周围的细胞反应

• 批准号: 02670789
• 负责人: ISHIBASHI Tatsuro
• 金额: $ 1.54万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670789/
• 关键词: Intraocular lens; After cataract; Fibrous opacification; Lens epithelial cell; Anterior capsule opacification; Collagen fiber; Transmission electron microscopy; Macrophage; 線維性混濁; 前嚢混濁; 膠原線維; マクロファ-ジ; マイクロフィラメント; フィブロネクチン; トレ-サ-

We performed posterior chamber lens implantation(IOL) in three monkey eyes. All pseudophakic eyes developed a ring-shaped opacity, appearing on the IOL optics along the anterior capsule incision line. Transmission electron microscopic study revealed that the anterior capsule opacification was composed of proliferated cellular and extracellular components between the anterior capsule and the IOL optics. The proliferated cells looked like fibroblasts, but they were connected by desmosomes and covered by basal lamina. These histologic findings represented morphological features of epithelial cells, probably lens epithelial cells. Extracellular components consisted of collagen fibers, microfibrils, and basal lamina-like materials.Using transmission electron microscopy, we studied the surface of five IOLs. All five lenses had poly(methyl)methacrylate optics and had been removed from human eyes because of the dislocation. The surface of each lens was smooth and covered by a thin membrane-like structure. Two lenses showed cellular deposits on the membrane-like structure that covered it. The cellular deposits were composed of macrophages and giant cells, many of which were multinucleated, and were scattered over the surface of the IOL. A mild cellular reaction to the IOL was noted in two cases; however, a typical foreign body granuloma was not seen in any of these five cases.

我们对三只猴眼进行了后房型人工晶状体植入术。所有假晶状体眼沿前囊切口线出现环状混浊。透射电镜显示前囊混浊是由前囊与人工晶状体之间增生的细胞和细胞外成分组成的。增生的细胞看起来像成纤维细胞，但它们由桥粒连接并被基层覆盖。这些组织学结果反映了上皮细胞的形态学特征，可能是晶状体上皮细胞。细胞外成分包括胶原纤维、微原纤维和基底层样物质。利用透射电镜对5个人工晶状体的表面进行了研究。所有五个晶状体都是聚甲基丙烯酸甲酯光学，由于脱位而从人眼中取出。每个晶状体表面光滑，表面覆盖一层薄膜状结构。两个晶状体上覆盖的膜状结构上有细胞沉积。细胞沉积物由巨噬细胞和巨细胞组成，其中许多是多核的，分散在人工晶状体表面。2例患者对人工晶状体有轻度细胞反应；然而，在这5例病例中均未见典型的异物肉芽肿。

项目成果

Ishibashi,T.: "Cellular reaction on the surface of intraocular lenses removed from human eyes" J Cataract Refract Surg. 16. 751-754 (1990)

Ishibashi,T.：“从人眼取出的人工晶状体表面的细胞反应”J Cataract Refract Surg。

石橋 達朗: "眼内レンズセミナ- 46.眼内レンズの病理ーフィブリン反応" あたらしい眼科. 7. 857-858 (1990)

Tatsuro Ishibashi：“人工晶状体研讨会 - 46. 人工晶状体病理学 - 纤维蛋白反应”新眼科杂志 7. 857-858 (1990)。

石橋 達朗: "眼の組織・病理アトラス56 眼内レンズ" 臨床眼科. 45. 898-899 (1991)

Tatsuro Ishibashi：“眼组织学和病理学图谱 56 人工晶状体”临床眼科 45. 898-899 (1991)。

Ishibashi,T.: "Cellular adhesiveness on implanted lenses in Monkeys" Graefe's Arch Clin Exp Ophthalmol. 228. 356-362 (1990)

Ishibashi,T.：“猴子植入晶状体的细胞粘附性”Graefe 的 Arch Clin Exp Ophamol。

Ishibashi,T.: "Fine structure on top of intraocular lens surface: a transmission electron microscopic study" Cells and Materials. 1. 301-306 (1991)

Ishibashi,T.：“人工晶状体表面顶部的精细结构：透射电子显微镜研究”细胞和材料。