CELLULAR REACTION AROUND THE INTRAOCULAR LENSES

我们对三只猴眼进行了后房型人工晶状体植入术。所有假晶状体眼沿前囊切口线出现环状混浊。透射电镜显示前囊混浊是由前囊与人工晶状体之间增生的细胞和细胞外成分组成的。增生的细胞看起来像成纤维细胞，但它们由桥粒连接并被基层覆盖。这些组织学结果反映了上皮细胞的形态学特征，可能是晶状体上皮细胞。细胞外成分包括胶原纤维、微原纤维和基底层样物质。利用透射电镜对5个人工晶状体的表面进行了研究。所有五个晶状体都是聚甲基丙烯酸甲酯光学，由于脱位而从人眼中取出。每个晶状体表面光滑，表面覆盖一层薄膜状结构。两个晶状体上覆盖的膜状结构上有细胞沉积。细胞沉积物由巨噬细胞和巨细胞组成，其中许多是多核的，分散在人工晶状体表面。2例患者对人工晶状体有轻度细胞反应；然而，在这5例病例中均未见典型的异物肉芽肿。

We performed posterior chamber lens implantation(IOL) in three monkey eyes. All pseudophakic eyes developed a ring-shaped opacity, appearing on the IOL optics along the anterior capsule incision line. Transmission electron microscopic study revealed that the anterior capsule opacification was composed of proliferated cellular and extracellular components between the anterior capsule and the IOL optics. The proliferated cells looked like fibroblasts, but they were connected by desmosomes and covered by basal lamina. These histologic findings represented morphological features of epithelial cells, probably lens epithelial cells. Extracellular components consisted of collagen fibers, microfibrils, and basal lamina-like materials.Using transmission electron microscopy, we studied the surface of five IOLs. All five lenses had poly(methyl)methacrylate optics and had been removed from human eyes because of the dislocation. The surface of each lens was smooth and covered by a thin membrane-like structure. Two lenses showed cellular deposits on the membrane-like structure that covered it. The cellular deposits were composed of macrophages and giant cells, many of which were multinucleated, and were scattered over the surface of the IOL. A mild cellular reaction to the IOL was noted in two cases; however, a typical foreign body granuloma was not seen in any of these five cases.