CELLULAR REACTION AROUND THE INTRAOCULAR LENSES

我们对3只猴眼进行了后房型人工晶状体植入术。所有人工晶状体眼均出现环状混浊，沿着前囊切口线出现在人工晶状体上。透射电子显微镜观察发现，前囊混浊是由前囊与人工晶状体之间增殖的细胞和细胞外成分组成。增殖的细胞看起来像成纤维细胞，但它们之间由桥粒连接，并被基底膜覆盖。这些组织学表现了上皮细胞的形态特征，可能是晶状体上皮细胞。细胞外成分主要由胶原纤维、微纤维和基底板状材料组成。所有五个镜片都是聚甲基丙烯酸甲酯光学元件，由于脱位，已经从人眼中取出。每个晶状体表面光滑，表面覆盖有一层薄膜状结构。两个镜片显示覆盖它的膜状结构上有细胞沉积。细胞沉积物由巨噬细胞和巨细胞组成，其中许多为多核细胞，散布在人工晶状体表面。在两个病例中观察到对人工晶状体的轻微细胞反应；然而，在这五个病例中没有一个见到典型的异物肉芽肿。

We performed posterior chamber lens implantation(IOL) in three monkey eyes. All pseudophakic eyes developed a ring-shaped opacity, appearing on the IOL optics along the anterior capsule incision line. Transmission electron microscopic study revealed that the anterior capsule opacification was composed of proliferated cellular and extracellular components between the anterior capsule and the IOL optics. The proliferated cells looked like fibroblasts, but they were connected by desmosomes and covered by basal lamina. These histologic findings represented morphological features of epithelial cells, probably lens epithelial cells. Extracellular components consisted of collagen fibers, microfibrils, and basal lamina-like materials.Using transmission electron microscopy, we studied the surface of five IOLs. All five lenses had poly(methyl)methacrylate optics and had been removed from human eyes because of the dislocation. The surface of each lens was smooth and covered by a thin membrane-like structure. Two lenses showed cellular deposits on the membrane-like structure that covered it. The cellular deposits were composed of macrophages and giant cells, many of which were multinucleated, and were scattered over the surface of the IOL. A mild cellular reaction to the IOL was noted in two cases; however, a typical foreign body granuloma was not seen in any of these five cases.