CELLULAR REACTION AROUND THE INTRAOCULAR LENSES

我们在三只猴子的眼睛中进行了后房透镜植入术（IOL）。所有人工晶状体眼均出现环形混浊，沿前囊切开线沿着出现在IOL光学部上。透射电镜观察显示，前囊混浊由前囊和人工晶状体光学部之间的增殖细胞和细胞外成分组成。增殖的细胞看起来像成纤维细胞，但它们由桥粒连接并被基底膜覆盖。这些组织学发现代表上皮细胞的形态学特征，可能是透镜上皮细胞。细胞外成分包括胶原纤维、微纤维和基底膜样物质。所有5枚晶状体均具有聚（甲基）甲基丙烯酸酯光学部，并且由于脱位而从人眼中取出。每个透镜的表面是光滑的并且被薄膜状结构覆盖。两个晶状体在覆盖其的膜样结构上显示细胞沉积物。细胞沉积物由巨噬细胞和巨细胞组成，其中许多是多核的，并分散在IOL表面。在两例病例中观察到对人工晶状体的轻度细胞反应;然而，在这五例病例中均未观察到典型的异物肉芽肿。

We performed posterior chamber lens implantation(IOL) in three monkey eyes. All pseudophakic eyes developed a ring-shaped opacity, appearing on the IOL optics along the anterior capsule incision line. Transmission electron microscopic study revealed that the anterior capsule opacification was composed of proliferated cellular and extracellular components between the anterior capsule and the IOL optics. The proliferated cells looked like fibroblasts, but they were connected by desmosomes and covered by basal lamina. These histologic findings represented morphological features of epithelial cells, probably lens epithelial cells. Extracellular components consisted of collagen fibers, microfibrils, and basal lamina-like materials.Using transmission electron microscopy, we studied the surface of five IOLs. All five lenses had poly(methyl)methacrylate optics and had been removed from human eyes because of the dislocation. The surface of each lens was smooth and covered by a thin membrane-like structure. Two lenses showed cellular deposits on the membrane-like structure that covered it. The cellular deposits were composed of macrophages and giant cells, many of which were multinucleated, and were scattered over the surface of the IOL. A mild cellular reaction to the IOL was noted in two cases; however, a typical foreign body granuloma was not seen in any of these five cases.