Challenge to the world's first drug delivery system having a drug-concentration sensing function

挑战全球首个具有药物浓度传感功能的给药系统

• 批准号: 24659873
• 负责人: YOSHIDA Yasuhiro
• 金额: $ 2.33万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659873/
• 关键词: ドラッグデリバリーシステム; DDS; 担体; リン酸化プルラン; 塩化セチルピリジニウム; CPC; 濃度; 抗菌; 多糖誘導体; リン酸化多糖; ミセル; 抗菌剤; 高度変化; 濃度変化; イオン結合; 疎水性相互作用

To develop the world's first drug delivery system having a drug-concentration sensing function, we synthesized phosphorylated pullulan (PPL) with several phosphorylation ratios as the carrier for bactericide delivery. Only cetylpyridinium chloride (CPC) showed no effect on bacterial growth after slight rinsing, even at a high concentration of CPC. However, it was revealed that the complex of 0.01% PPL and 0.01% CPC (0.01% PPL-CPC) consistently exhibited an antibacterial effect, even after rinsing with distilled water. Although 0.02% PPL-CPC also showed an excellent antibacterial effect like 0.01% PPL-CPC, 0.03, 0.04 and 0.05% PPL-CPC have no effect on bacterial growth after slight rinsing. These facts indicated that PPL is available as a carrier for drug delivery system having a drug-concentration sensing function.

为了开发世界上第一个具有药物浓度传感功能的药物递送系统，我们合成了具有几种磷酸化比例的磷酸化普鲁兰（PPL）作为药物递送的载体。只有氯化十六烷基吡啶（CPC）轻微冲洗后，即使在高浓度的CPC对细菌生长没有影响。然而，结果表明，0.01%PPL和0.01%CPC的复合物（0. 01% PPL-CPC）即使在用蒸馏水冲洗后也始终表现出抗菌效果。0.02%的PPL-CPC与0.01%的PPL-CPC一样具有良好的抗菌效果，但0.03%、0.04%和0.05%的PPL-CPC在轻微冲洗后对细菌生长没有影响。这些事实表明，PPL可用作具有药物浓度传感功能的药物递送系统的载体。

项目成果

Key Engineering Materials Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping

用于直接盖髓的关键工程材料可见光诱导交联明胶

• 发表时间: 2013
• 作者: Nakamura;M.;Yoshida;Y.;Ito;Y
• 通讯作者: Y

Novel Fluoro-carbon Functional Monomer for Dental Bonding

• DOI: 10.1177/0022034513514447
• 发表时间: 2014-02-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Yoshihara, K.;Yoshida, Y.;Van Meerbeek, B.
• 通讯作者: Van Meerbeek, B.

HEMA Inhibits Interfacial Nano-layering of the Functional Monomer MDP

• DOI: 10.1177/0022034512460396
• 发表时间: 2012-11-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Yoshida, Y.;Yoshihara, K.;Van Meerbeek, B.
• 通讯作者: Van Meerbeek, B.

Flavonol-containing phosphorylated pullulan may attenuate pulp inflammation

含黄酮醇的磷酸化普鲁兰多糖可以减轻牙髓炎症

• DOI: 10.1111/j.1365-2591.2012.02095.x
• 发表时间: 2013
• 期刊: Int. Endod. J.
• 作者: K.Kishihara;M.Naito;Y.Okahata;J. Yonehiro
• 通讯作者: J. Yonehiro

Preparation of low-crystalline apatite nanoparticles and their coating onto quartz substrates

低结晶磷灰石纳米粒子的制备及其在石英基底上的涂层

• DOI: 10.1007/s10856-012-4614-6
• 发表时间: 2012
• 期刊: J. Mater. Sci. Mater. Med.
• 作者: Kenichi Harimoto;Yasuhiro Yoshida;Kumiko Yoshihara;Noriyuki Nagaoka;Takuya Matsumoto;Yoh-ichi Tagawa;M. Kawashita
• 通讯作者: M. Kawashita