Theoretical molecular-design of a functional monomer for development of high-functinally adhesives

用于开发高功能粘合剂的功能单体的理论分子设计

基本信息

  • 批准号:
    14571848
  • 负责人:
  • 金额:
    $ 2.56万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2002
  • 资助国家:
    日本
  • 起止时间:
    2002 至 2003
  • 项目状态:
    已结题

项目摘要

Commonly, acidic monomers in self-etch primers/adhesives are esters originating from the reaction of a bivalent alcohol with methacrylic acid and phosphoric/carboxylic acid derivatives. Each self-etch adhesive contains its specific functional monomer that to a large extent determines its actual adhesive performance. Thus far however, the interaction of functional monomers, with dental tissues has seldom been characterized using chemical analytical techniques. We therefore characterized the adhesive interaction of three functional monomers chemically with synthetic hydroxyapatite using X-ray Photoelectron Spectroscopy and Atomic Absorption Spectrophotometry, and ultra-morphologically with dentin using Transmission Electron Microscopy. High-resolution microscopic analysis showed that all three self-etch adhesives hybridized dentin, indicating that their bonding mechanism at least in part depended on micro-mechanical interlocking of resin into a micro-porous surface. In contrast to etch-and-rinse adhesives that involve phosphoric-acid etching, the self-etch adhesives only partially demineralized dentin, leaving hydroxyapatite partially attached to collagen. Knowing that hydroxyapatite remains available for interaction, the main objective of this study was to characterize any potential chemical interaction the functional monomers may have with this residual hydroxyapatite. The monomer 10-methacryloxydecyl dihydrogen phosphate (10-MDP) readily adhered to hydroxyapatite. This bond appeared very stable, as confirmed by the low dissolution rate of its calcium salt in water. The bonding potential of 4-methacryloxyethyl trimellitic acid (4-MET) was substantially lower. The monomer 2-methacryloxyethyl phenyl hydrogen phosphate (phenyl-P) and its bond to hydroxyapatite appeared not very hydrolytically stable. Besides self-etching dentin, specific functional, monomers have an additional chemical bonding efficacy that is expected to contribute to adhesive performance.
通常,自蚀刻底漆/粘合剂中的酸性单体是由二价醇与甲基丙烯酸和磷酸/羧酸衍生物反应产生的酯。每种自蚀刻胶都含有其特定的功能单体,这些功能单体在很大程度上决定了其实际的粘合性能。然而,到目前为止,功能单体与牙齿组织的相互作用很少用化学分析技术来表征。因此,我们使用x射线光电子能谱和原子吸收分光光度法对三种功能单体与合成羟基磷灰石的粘附相互作用进行了化学表征,并使用透射电镜对其与牙本质的超形态学进行了表征。高分辨率显微分析显示,这三种自蚀刻粘合剂都与牙本质杂交,表明它们的结合机制至少在一定程度上取决于树脂与微孔表面的微机械联锁。与涉及磷酸蚀刻的蚀刻-冲洗胶粘剂相比,自蚀刻胶粘剂仅部分脱矿牙本质,留下部分羟基磷灰石附着在胶原蛋白上。知道羟基磷灰石仍然可以相互作用,本研究的主要目的是表征功能单体可能与羟基磷灰石残留的任何潜在的化学相互作用。单体10-甲基丙烯氧基癸基磷酸二氢(10-MDP)极易与羟基磷灰石吸附。其钙盐在水中的低溶解速率证实了这种键的稳定性。4-甲基丙烯氧基乙基三戊酸(4-MET)的成键电位明显较低。单体2-甲基丙烯氧乙基苯基磷酸氢(phenyl- p)及其与羟基磷灰石的结合表现出不太好的水解稳定性。除了自蚀刻牙本质外,特定功能单体还具有额外的化学粘合功效,有望有助于粘合剂性能。

项目成果

期刊论文数量(52)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yoshida, Y, et al.: "Filler Decontamination on Aesthetics and Degradation Resistance of Resin Composites."Dental Materials Journal. 21. 383-395 (2002)
Yoshida, Y 等人:“填料净化对树脂复合材料的美观和耐降解性的影响。”牙科材料杂志。
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    0
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Fukuda, R, Y.Yoshida, Y.Nakayama, M.Okazaki, S.Inoue, H., Sano, K.Suzuki, H.Shintani, B.Van Meerbeek: "Bonding efficacy of polyalkenoic acids to hydroxyapatite, enamel and dentin"Biomaterials. 24. 1861-1867 (2003)
Fukuda, R, Y.Yoshida, Y.Nakayama, M.Okazaki, S.Inoue, H., Sano, K.Suzuki, H.Shintani, B.Van Meerbeek:“聚链烯酸对羟基磷灰石、牙釉质和牙本质的粘合功效
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    0
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Yoshida, Y., Shirai, K., H.Shintani, H., Okazaki, M., Suzuki, K., Van Meerbeek, B.: "Effect of Presilanization Filler Decontamination on Aesthetics and Degradation Resistance of Resin Composites."Dental Materials Journal. 21. 383-395 (2002)
Yoshida, Y.、Shirai, K.、H.Shintani, H.、Okazaki, M.、Suzuki, K.、Van Meerbeek, B.:“预硅烷化填料去污对树脂复合材料的美观和耐降解性的影响。”牙科
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    0
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Yoshida, Y., Van Meerbeek, B., Suzuki, K.: "Nanotechnological research on mechanisms of tooth bonding"the Quintessence. 23. 807-813 (2004)
Yoshida, Y.、Van Meerbeek, B.、Suzuki, K.:“牙齿粘合机制的纳米技术研究”精髓。
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    0
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Fukuda, R., Yoshida, Y., Van Meerbeek, B., Okazaki, M., Suzuki, M., Shintani, H.: "Chemical bonding potential of polyalkenoic acids to enamel and dentin."Archives of BioCeramics Research. Volume 3. 89-94 (2003)
Fukuda, R.、Yoshida, Y.、Van Meerbeek, B.、Okazaki, M.、Suzuki, M.、Shintani, H.:“聚链烯酸与牙釉质和牙本质的化学键合潜力。”生物陶瓷研究档案。
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YOSHIDA Yasuhiro其他文献

YOSHIDA Yasuhiro的其他文献

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{{ truncateString('YOSHIDA Yasuhiro', 18)}}的其他基金

Development of antibacterial materials for prevention and treatment of peri-implantitis
防治种植体周围炎抗菌材料的开发
  • 批准号:
    26670836
  • 财政年份:
    2014
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
An evaluation of environmental pollutant exposure using cell survival signaling and development of simple detection system
利用细胞生存信号评估环境污染物暴露并开发简单检测系统
  • 批准号:
    24390159
  • 财政年份:
    2012
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Challenge to the world's first drug delivery system having a drug-concentration sensing function
挑战全球首个具有药物浓度传感功能的给药系统
  • 批准号:
    24659873
  • 财政年份:
    2012
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Targeting DDS with sensing function of tissular and environmental changes
具有组织和环境变化传感功能的靶向 DDS
  • 批准号:
    22659357
  • 财政年份:
    2010
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Nano-scale analysis and control of biomaterial-hard tissue interfaces.
生物材料-硬组织界面的纳米级分析和控制。
  • 批准号:
    21390514
  • 财政年份:
    2009
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
BDNF produced by leukemia cells induced regulatory T cells
白血病细胞诱导调节性T细胞产生BDNF
  • 批准号:
    21591253
  • 财政年份:
    2009
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effect of BDNF on proliferation of leukemic cells and application to the treatment.
BDNF对白血病细胞增殖的影响及其在治疗中的应用
  • 批准号:
    19591147
  • 财政年份:
    2007
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
High Performance Ti implant by photo-immobilization of cytokine and its effect oncell adhesion, proliferation and differentiation
光固定细胞因子的高性能钛植入物及其对细胞粘附、增殖和分化的影响
  • 批准号:
    18390513
  • 财政年份:
    2006
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of functional Ti implants with release of growth factors
开发释放生长因子的功能性钛植入物
  • 批准号:
    16390557
  • 财政年份:
    2004
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

相似海外基金

Development of adhesive system of one-step self-etch adhesive with a high bond durability
开发具有高粘合耐久性的一步式自蚀刻粘合剂的粘合系统
  • 批准号:
    25462969
  • 财政年份:
    2013
  • 资助金额:
    $ 2.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
SELF-ETCH BOND AGENT IN THE RESTORATION OF NON-CARIOUS CERVICAL LESIONS
自蚀粘结剂在非龋性宫颈病变修复中的应用
  • 批准号:
    7604832
  • 财政年份:
    2007
  • 资助金额:
    $ 2.56万
  • 项目类别:
SELF-ETCH BOND AGENT IN THE RESTORATION OF NON-CARIOUS CERVICAL LESIONS
自蚀粘结剂在非龋性宫颈病变修复中的应用
  • 批准号:
    7377040
  • 财政年份:
    2006
  • 资助金额:
    $ 2.56万
  • 项目类别:
SELF-ETCH BOND AGENT IN THE RESTORATION OF NON-CARIOUS CERVICAL LESIONS
自蚀粘结剂在非龋性宫颈病变修复中的应用
  • 批准号:
    7201373
  • 财政年份:
    2005
  • 资助金额:
    $ 2.56万
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