Social events – An event coding approach to echophenomena in GTS

社会事件 â GTS 中回声现象的事件编码方法

• 批准号: 396576876
• 负责人: Professor Dr. Sören Krach
• 金额: --
• 依托单位: Klinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/396576876?language=en
• 关键词: Social; events; event; coding; approach

Echophenomena belong to the core symptoms of GTS, being present in at least 20-30% of GTS patients and distinguishing ‘pure’ GTS from the most common comorbidities ADHD and OCD. Echophenomena in GTS comprise both echopraxia, denoting the automatic imitation of others’ actions, and echolalia, referring to repetitions of sounds and language. Although echophenomena are very common, there is only little empirical work delineating the cognitive and neural mechanisms underlying automatic imitation in GTS. Common coding approaches to action and perception including the Theory of Event Coding (TEC) are suitable candidates to conceptualize automatic imitation, which can be considered the prime example of action-perception matching. This theoretical framework and behavioural evidence is dovetailed by a decade of research on the ‘mirror neuron system’ as the putative neurobiological basis of a joint representation of action and perception. Such joint representation has been demonstrated to be relevant not only for understanding others’ actions, but also others’ sensations and emotions. This raises the questions whether echophenomena in GTS relate (i) to altered functioning of the mirror neuron system and (ii) more generally to an altered neural representation of others’ sensations and emotions. With the present project, we aim to address these questions with a series of EEG- and fMRI-studies.

幻视现象属于GTS的核心症状，存在于至少20-30%的GTS患者中，并将“纯”GTS与最常见的合并症ADHD和OCD区分开来。GTS中的回声现象包括echopraxia和echolalia，echolalia指的是声音和语言的重复。虽然echphenomena是很常见的，只有很少的实证工作描绘的认知和神经机制自动模仿GTS。包括事件编码理论（TEC）在内的动作和感知的常见编码方法是将自动模仿概念化的合适候选者，这可以被认为是动作-感知匹配的主要例子。这一理论框架和行为证据被十年来对“镜像神经元系统”的研究所证实，镜像神经元系统是行动和感知的联合表征的假定神经生物学基础。这种联合表征不仅与理解他人的行为有关，而且与理解他人的感觉和情绪有关。这就提出了一个问题，即GTS中的回声现象是否与（i）镜像神经元系统的功能改变有关，以及（ii）更普遍地与其他感觉和情绪的神经表征改变有关。在本项目中，我们的目标是通过一系列EEG和fMRI研究来解决这些问题。