Neurophysiological correlates of the development of event file coding: a comparison of maturational and Tourette-related mechanisms

该研究单元的中心目标是使用事件编码理论（TEC）的框架来研究Gilles de la Tourette综合征（GTS）中感知和动作整合的神经机制如何改变，并深入了解抽搐和冲动的神经基础。GTS是一种典型的神经发育障碍，在大多数情况下，症状在儿童期发作，并在青春期出现年龄依赖性缓解。然而，它是迄今为止不清楚的皮质-纹状体-丘脑-皮质回路中的神经发育过程subserve '发育正常化'在GTS。为了填补这一空白，该项目将系统地比较行为和神经生理学相关的感知-动作事件编码，即感知分类，特征绑定和反应选择，在不同年龄段的患者和健康对照之间，代表Tourette综合征临床过程的关键阶段。该项目的预期结果将揭示有助于症状缓解的个体差异的机制，并将作为后续研究的起点，调查与行动计划的典型和非典型发展相关的神经生理学变化的纵向轨迹。

The central aim of this Research Unit is to use the framework of the Theory of Event Coding (TEC) to investigate how neural mechanisms of perception and action integration are altered in Gilles de la Tourette syndrome (GTS) and to gain insights into the neural basis of tics and urges. GTS is a prototypical neurodevelopmental disorder with symptom onset in childhood and age-dependent remission during adolescence in most cases. However, it is to date unclear which neurodevelopmental processes in cortico-striato-thalamo-cortical circuits subserve ‘developmental normalization’ in GTS. To fill this gap, this project will systematically compare behavioral and neurophysiological correlates of perception–action event coding, i.e. perceptual categorization, feature binding, and response selection, between patients and healthy controls across different age periods representing key phases of the clinical course of Tourette syndrome. Anticipated results of this project will shed light on mechanisms contributing to individual differences in symptom remission and will serve as the starting point of a follow-up study investigating longitudinal trajectories of neurophysiological changes that are associated with typical and atypical development of action planning.