Neurophysiological correlates of the development of event file coding: a comparison of maturational and Tourette-related mechanisms

事件文件编码发展的神经生理学相关性：成熟机制和抽动秽语相关机制的比较

• 批准号: 396577296
• 负责人: Professorin Shu-Chen Li, Ph.D.
• 金额: --
• 依托单位: Professur für Entwicklungspsychologie und Neurowissenschaft der Lebensspanne
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/396577296?language=en
• 关键词: Neurophysiological; correlates; development; event; file

The central aim of this Research Unit is to use the framework of the Theory of Event Coding (TEC) to investigate how neural mechanisms of perception and action integration are altered in Gilles de la Tourette syndrome (GTS) and to gain insights into the neural basis of tics and urges. GTS is a prototypical neurodevelopmental disorder with symptom onset in childhood and age-dependent remission during adolescence in most cases. However, it is to date unclear which neurodevelopmental processes in cortico-striato-thalamo-cortical circuits subserve ‘developmental normalization’ in GTS. To fill this gap, this project will systematically compare behavioral and neurophysiological correlates of perception–action event coding, i.e. perceptual categorization, feature binding, and response selection, between patients and healthy controls across different age periods representing key phases of the clinical course of Tourette syndrome. Anticipated results of this project will shed light on mechanisms contributing to individual differences in symptom remission and will serve as the starting point of a follow-up study investigating longitudinal trajectories of neurophysiological changes that are associated with typical and atypical development of action planning.

本研究单元的中心目标是利用事件编码理论（TEC）的框架来研究吉尔斯·德·拉·图雷特综合征（GTS）中感知和行动整合的神经机制是如何改变的，并深入了解抽搐和冲动的神经基础。GTS是一种典型的神经发育障碍，症状发作于儿童期，大多数情况下在青春期年龄依赖性缓解。然而，迄今为止尚不清楚皮质-纹状体-丘脑-皮质回路中的哪些神经发育过程服务于GTS的“发育正常化”。为了填补这一空白，本项目将系统地比较不同年龄阶段的患者和健康对照之间感知-行动事件编码的行为和神经生理相关，即感知分类、特征绑定和反应选择，这些阶段代表了图雷特综合征临床过程的关键阶段。该项目的预期结果将阐明导致症状缓解的个体差异的机制，并将作为后续研究的起点，调查与典型和非典型行动计划发展相关的神经生理变化的纵向轨迹。