Neurophysiological Correlates of Visual Motion Processing in Cerebral Visual Impairment

脑视觉障碍中视觉运动处理的神经生理学相关性

• 批准号: 10669646
• 负责人: Lotfi Merabet
• 金额: $ 25.6万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669646
• 关键词: Adolescent; Anisotropy; Attention; Behavior assessment; Behavioral; Brain; Cerebrum; Child; Child Care; Clinical assessments; Complex; Development; Diffusion; Dorsal; Education; Environment; Eye Movements; Fiber; Functional Magnetic Resonance Imaging; Functional disorder; Image; Impairment; Individual; Interdisciplinary Study; Investigation; Length; Magnetic Resonance Imaging; Motion; Motion Perception; Multimodal Imaging; Nature; Network-based; Neuronal Plasticity; Outcome; Outcome Measure; Parietal; Participant; Pathway interactions; Pattern; Performance; Perinatal; Periventricular Leukomalacia; Population; Predisposition; Psychophysics; Rehabilitation therapy; Reporting; Research; Resolution; Rest; Signal Transduction; Stream; Structure; Testing; Time; United States; Visual; Visual Motion; Visual Pathways; Visual Psychophysics; Visual System; Visual attention; Visual impairment; behavior test; blood oxygen level dependent; clinical development; community involvement; comparison control; cortical visual impairment; design; gaze; imaging approach; indexing; innovation; insight; interest; multimodal neuroimaging; multimodality; neural correlate; neuroimaging; neurological rehabilitation; neurophysiology; programs; response; secondary outcome; statistics; virtual reality; virtual reality simulation; visual processing; visual search; white matter

Summary Cerebral (cortical) visual impairment (CVI) is the leading cause of congenital vision impairment in the United States. Yet, there remains an alarming gap in our understanding as to how observed visual perceptual deficits in these individuals relate to perinatal damage and early maldevelopment of central visual pathways and structures. Children and adolescents with CVI show striking impairments in complex motion processing (a dorsal stream function), particularly in the setting of complex dynamic environmental scenes. While impaired motion perception is an important marker of developmental vulnerability (referred to as the dorsal stream dysfunction hypothesis), standard ophthalmic clinical assessments fail to capture and fully characterize these visual deficits. Thus, in the absence of any apparent ocular abnormality, clinicians may dismiss reported perceptual difficulties, and many individuals with CVI will remain undiagnosed and never receive the timely education and rehabilitative support they need. The objective of the proposed research is to investigate the underlying neurophysiology associated with motion processing deficits in CVI. We will carry out psychophysical behavioral testing combined with multimodal neuroimaging (to characterize structural and functional connectivity along with brain network activation) in children and adolescents with CVI associated with periventricular leukomalacia (PVL). Indices of behavioral performance and neuroimaging outcomes will be compared to neurotypical controls. Our overarching hypothesis is that motion processing deficits will be associated with the maldevelopment of key visual processing pathways. However, altered patterns of functional connectivity and activation of brain networks implicated in complex motion perception may serve as indicators of compensatory neuroplasticity. In our first aim, we will assess motion processing abilities using random dot kinematograms, virtual reality simulations, and visual search tasks. In our second aim, we will characterize the integrity and topology of structural and functional connectivity networks (using high angular resolution diffusion imaging and resting state fMRI respectively) implicated with visual motion and attention processing. The third aim will investigate brain network activation (using functional MRI) in response to our behavioral task assessments. Executed by a multidisciplinary research team with strong community involvement, this combined behavioral assessment and multimodal imaging approach represents a key distinguishing innovation of the proposal. This study will provide convergent and high-level insights into the neurophysiological basis of visual motion perceptual deficits in CVI. The proposed program of research is highly significant given that uncovering brain-behavioral associations in the case of CVI represents a crucial step in establishing a neurorehabilitative framework specifically designed for the care of these children; a population that has been greatly underserved despite its important

总结

项目成果

Motion and form coherence processing in individuals with cerebral visual impairment.

脑视觉障碍个体的运动和形式连贯性处理。

• DOI: 10.1111/dmcn.15591
• 发表时间: 2023
• 期刊: Developmental medicine and child neurology
• 影响因子: 3.8
• 作者: Merabet,LotfiB;Manley,ClaireE;Pamir,Zahide;Bauer,CorinnaM;Skerswetat,Jan;Bex,PeterJ
• 通讯作者: Bex,PeterJ

Visual perception supported by verbal mediation in an individual with cerebral visual impairment (CVI).

• DOI: 10.1016/j.neuropsychologia.2021.107982
• 发表时间: 2021-09-17
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: Pamir Z;Bauer CM;Bennett CR;Kran BS;Merabet LB
• 通讯作者: Merabet LB

Assessing visuospatial processing in cerebral visual impairment using a novel and naturalistic static visual search task.

• DOI: 10.1016/j.ridd.2022.104364
• 发表时间: 2022-12
• 期刊: RESEARCH IN DEVELOPMENTAL DISABILITIES
• 影响因子: 3.1
• 作者: Zhang, Xin;Manley, Claire E.;Micheletti, Serena;Tesic, Isidora;Bennett, Christopher R.;Fazzi, Elisa M.;Merabet, Lotfi B.
• 通讯作者: Merabet, Lotfi B.

Assessing Higher-Order Visual Processing in Cerebral Visual Impairment Using Naturalistic Virtual-Reality-Based Visual Search Tasks.

• DOI: 10.3390/children9081114
• 发表时间: 2022-07-26
• 期刊: CHILDREN-BASEL
• 影响因子: 2.4
• 作者: Manley, Claire E.;Bennett, Christopher R.;Merabet, Lotfi B.
• 通讯作者: Merabet, Lotfi B.

Altered neural oscillations underlying visuospatial processing in cerebral visual impairment.

脑视觉障碍中视觉空间处理的神经振荡发生改变。

• DOI: 10.1093/braincomms/fcad232
• 发表时间: 2023
• 期刊: Brain communications
• 影响因子: 4.8
• 作者: Federici,Alessandra;Bennett,ChristopherR;Bauer,CorinnaM;Manley,ClaireE;Ricciardi,Emiliano;Bottari,Davide;Merabet,LotfiB
• 通讯作者: Merabet,LotfiB