Neurophysiological Correlates of Visual Motion Processing in Cerebral Visual Impairment

脑视觉障碍中视觉运动处理的神经生理学相关性

基本信息

  • 批准号:
    10251145
  • 负责人:
  • 金额:
    $ 24.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-30 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Summary Cerebral (cortical) visual impairment (CVI) is the leading cause of congenital vision impairment in the United States. Yet, there remains an alarming gap in our understanding as to how observed visual perceptual deficits in these individuals relate to perinatal damage and early maldevelopment of central visual pathways and structures. Children and adolescents with CVI show striking impairments in complex motion processing (a dorsal stream function), particularly in the setting of complex dynamic environmental scenes. While impaired motion perception is an important marker of developmental vulnerability (referred to as the dorsal stream dysfunction hypothesis), standard ophthalmic clinical assessments fail to capture and fully characterize these visual deficits. Thus, in the absence of any apparent ocular abnormality, clinicians may dismiss reported perceptual difficulties, and many individuals with CVI will remain undiagnosed and never receive the timely education and rehabilitative support they need. The objective of the proposed research is to investigate the underlying neurophysiology associated with motion processing deficits in CVI. We will carry out psychophysical behavioral testing combined with multimodal neuroimaging (to characterize structural and functional connectivity along with brain network activation) in children and adolescents with CVI associated with periventricular leukomalacia (PVL). Indices of behavioral performance and neuroimaging outcomes will be compared to neurotypical controls. Our overarching hypothesis is that motion processing deficits will be associated with the maldevelopment of key visual processing pathways. However, altered patterns of functional connectivity and activation of brain networks implicated in complex motion perception may serve as indicators of compensatory neuroplasticity. In our first aim, we will assess motion processing abilities using random dot kinematograms, virtual reality simulations, and visual search tasks. In our second aim, we will characterize the integrity and topology of structural and functional connectivity networks (using high angular resolution diffusion imaging and resting state fMRI respectively) implicated with visual motion and attention processing. The third aim will investigate brain network activation (using functional MRI) in response to our behavioral task assessments. Executed by a multidisciplinary research team with strong community involvement, this combined behavioral assessment and multimodal imaging approach represents a key distinguishing innovation of the proposal. This study will provide convergent and high-level insights into the neurophysiological basis of visual motion perceptual deficits in CVI. The proposed program of research is highly significant given that uncovering brain-behavioral associations in the case of CVI represents a crucial step in establishing a neurorehabilitative framework specifically designed for the care of these children; a population that has been greatly underserved despite its important
总结 大脑(皮质)视力障碍(CVI)是美国先天性视力障碍的主要原因。 States.然而,在我们的理解中,关于观察到的视觉感知缺陷是如何发生的, 在这些个体中与围产期损伤和中央视觉通路的早期发育不良有关, 结构.患有CVI的儿童和青少年在复杂的运动处理中表现出明显的损伤(a 背流函数),特别是在复杂动态环境场景的设置中。在身体受损时 运动知觉是发育脆弱性的重要标志(称为背流 功能障碍假说),标准眼科临床评估未能捕获和充分表征这些 视觉缺陷因此,在没有任何明显的眼部异常的情况下,临床医生可能会忽略报告的 知觉困难,许多患有CVI的人将仍然未被诊断,永远不会得到及时的治疗。 他们需要的教育和康复支持这项研究的目的是调查 与CVI中运动处理缺陷相关的潜在神经生理学。我们会对他进行心理物理检查 结合多模式神经成像的行为测试(以表征结构和功能 与脑血管病相关的儿童和青少年中的脑血管连通性沿着大脑网络激活) 脑室周围白质软化(PVL)。行为表现和神经影像学结果的指标将是 与正常对照组相比。我们的总体假设是,运动处理缺陷将是 与关键视觉处理通路的发育不良有关。然而, 复杂运动感知中涉及的大脑网络的功能连接和激活可能可以作为 代偿性神经可塑性的指标在我们的第一个目标,我们将评估运动处理能力, 随机点运动图、虚拟现实模拟和视觉搜索任务。在我们的第二个目标中,我们将 描述结构和功能连接网络的完整性和拓扑结构(使用高角度 分辨率弥散成像和静息态功能磁共振成像)与视觉运动和注意力有关 处理.第三个目标将研究大脑网络激活(使用功能性MRI),以响应我们的研究。 行为任务评估。由具有强大社区的多学科研究团队执行 参与,这种结合行为评估和多模式成像方法是一个关键 突出提案创新。这项研究将提供聚合和高层次的见解, 视觉运动知觉缺陷的神经生理学基础。拟议的研究计划是 非常重要的是,在CVI的情况下,揭示大脑行为的关联是一个至关重要的 建立专门为照顾这些儿童而设计的神经康复框架的一步; a 尽管人口的重要性很大,

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Lotfi Merabet其他文献

Lotfi Merabet的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Lotfi Merabet', 18)}}的其他基金

Neurophysiological Correlates of Visual Motion Processing in Cerebral Visual Impairment
脑视觉障碍中视觉运动处理的神经生理学相关性
  • 批准号:
    10669646
  • 财政年份:
    2020
  • 资助金额:
    $ 24.91万
  • 项目类别:
Characterizing Large-scale Neuroplastic Changes in Cerebral Compared to Ocular Visual Impairment
与眼部视觉障碍相比,大脑中大规模神经塑性变化的特征
  • 批准号:
    10613539
  • 财政年份:
    2020
  • 资助金额:
    $ 24.91万
  • 项目类别:
Neurophysiological Correlates of Visual Motion Processing in Cerebral Visual Impairment
脑视觉障碍中视觉运动处理的神经生理学相关性
  • 批准号:
    10047300
  • 财政年份:
    2020
  • 资助金额:
    $ 24.91万
  • 项目类别:
Neurophysiological Correlates of Visual Motion Processing in Cerebral Visual Impairment
脑视觉障碍中视觉运动处理的神经生理学相关性
  • 批准号:
    10456902
  • 财政年份:
    2020
  • 资助金额:
    $ 24.91万
  • 项目类别:
Characterizing Large-scale Neuroplastic Changes in Cerebral Compared to Ocular Visual Impairment
与眼部视觉障碍相比,大脑中大规模神经塑性变化的特征
  • 批准号:
    10404942
  • 财政年份:
    2020
  • 资助金额:
    $ 24.91万
  • 项目类别:
Assessing Spatial Processing Deficits in Cerebral Visual Impairment (CVI) Using Virtual Reality
使用虚拟现实评估脑视觉障碍 (CVI) 的空间处理缺陷
  • 批准号:
    9807307
  • 财政年份:
    2019
  • 资助金额:
    $ 24.91万
  • 项目类别:
Assessing Spatial Processing Deficits in Cerebral Visual Impairment (CVI) Using Virtual Reality
使用虚拟现实评估脑视觉障碍 (CVI) 的空间处理缺陷
  • 批准号:
    10005388
  • 财政年份:
    2019
  • 资助金额:
    $ 24.91万
  • 项目类别:
Audio Based Navigation in the Blind
基于音频的盲人导航
  • 批准号:
    8018059
  • 财政年份:
    2010
  • 资助金额:
    $ 24.91万
  • 项目类别:
Audio Based Navigation in the Blind
基于音频的盲人导航
  • 批准号:
    8417709
  • 财政年份:
    2010
  • 资助金额:
    $ 24.91万
  • 项目类别:
Audio Based Navigation in the Blind
基于音频的盲人导航
  • 批准号:
    8212081
  • 财政年份:
    2010
  • 资助金额:
    $ 24.91万
  • 项目类别:

相似海外基金

Exploration of Anisotropy and Inhomogeneity of Ocean Boundary Layer Turbulence
海洋边界层湍流的各向异性和不均匀性探索
  • 批准号:
    2344156
  • 财政年份:
    2024
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Standard Grant
CAREER: Anisotropy-Directed Synthesis of Optically Active 1D van der Waals Nanocrystals and Development of Multiscale Solid State Chemistry Educational Activities
职业:光学活性一维范德华纳米晶体的各向异性定向合成和多尺度固态化学教育活动的发展
  • 批准号:
    2340918
  • 财政年份:
    2024
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Continuing Grant
Seismic Tomography Models for Alaska: Validation, Iteration, and Complex Anisotropy
阿拉斯加地震层析成像模型:验证、迭代和复杂各向异性
  • 批准号:
    2342129
  • 财政年份:
    2024
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Continuing Grant
CEDAR: Evaluating Ion Temperature Anisotropy in the Weakly Collisional F-region Ionosphere
CEDAR:评估弱碰撞 F 区电离层中的离子温度各向异性
  • 批准号:
    2330254
  • 财政年份:
    2023
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Standard Grant
A novel fluorescence anisotropy imaging for imaging nano-scale LLPS in living cells
一种用于活细胞中纳米级 LLPS 成像的新型荧光各向异性成像
  • 批准号:
    23K17398
  • 财政年份:
    2023
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Pioneering)
Origin of intracellular anisotropy investigated by FCS utilizing spatial information
利用空间信息的 FCS 研究细胞内各向异性的起源
  • 批准号:
    23K05776
  • 财政年份:
    2023
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Lower mantle seismic anisotropy and heterogeneities - insight from the thermoelastic properties of CaSiO3 perovskite
下地幔地震各向异性和异质性——从 CaSiO3 钙钛矿热弹性性质的洞察
  • 批准号:
    2240506
  • 财政年份:
    2023
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Continuing Grant
Synchrotron deformation experiments of olivine under the deep upper mantle conditions: Transient creep, plastic anisotropy, and the role of grain-boundary sliding.
上地幔深部条件下橄榄石的同步加速变形实验:瞬态蠕变、塑性各向异性和晶界滑动的作用。
  • 批准号:
    2322719
  • 财政年份:
    2023
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Continuing Grant
Advanced Research into Crystallographic Anisotropy & Nucleation Effects in single crystals (ARCANE)
晶体各向异性的高级研究
  • 批准号:
    EP/X025454/1
  • 财政年份:
    2023
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Research Grant
Collaborative Research: CSEDI: Integrating Seismic Anisotropy, Mantle Flow, and Rock Deformation in Subduction Zone Settings
合作研究:CSEDI:在俯冲带环境中整合地震各向异性、地幔流和岩石变形
  • 批准号:
    2154072
  • 财政年份:
    2022
  • 资助金额:
    $ 24.91万
  • 项目类别:
    Continuing Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了