Development of an integrated endoscopic system based on optical imaging and hyper-spectral data analysis for early gastrointestinal cancer detection

开发基于光学成像和高光谱数据分析的集成内窥镜系统，用于早期胃肠道癌症检测

• 批准号: 25560238
• 负责人: TOMIKAWA Morimasa
• 金额: $ 2.5万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25560238/
• 关键词: 画像診断システム; 分光学的解析; 人間医工学; 医用システム; 疑似的病理検査; ハイパースペクトルカメラ; 質量分析

We examined a possibility of our developed hyper spectral camera system for a diagnosis of colorectal cancer. During the endoscopic screening, hyper spectral camera by which the reflectance spectral data of 400-800nm for 640x480 pixels are captured. All lesions that appeared abnormal and normal mucosa around the lesion were targeted. Resected specimens of primary colorectal cancer and non-neoplastic mucosa were obtained and measured spectrum at several points of the colorectal mucosa. We evaluated accuracy of the ability for tumor detection by the hyper spectral camera system. The average reflection intensity rate of each categories are, normal mucosa; 0.96, hyperplastic polyp; 0.90, adenoma; 0.86 and adenocarcinoma; 0.60. The increased spectral absorption ex vivo at 510nm was observed. Tumor and non-tumor tissue could be discriminated with a sensitivity of 62-75% and a specificity of 83-85% in both in vivo and ex vivo experiment.

我们研究了我们开发的高光谱相机系统用于诊断结直肠癌的可能性。在内窥镜筛查过程中，高光谱相机可捕获640 x480像素的400- 800 nm反射光谱数据。靶向病变周围出现异常和正常粘膜的所有病变。取原发性结直肠癌和非肿瘤性结直肠粘膜切除标本，在结直肠粘膜的多个点测量光谱。我们评估了高光谱相机系统检测肿瘤的能力的准确性。各类型的平均反射强度比值分别为：正常粘膜0.96，增生性息肉0.90，腺瘤0.86，腺癌0.60。观察到离体510 nm处的光谱吸收增加。在体内和离体实验中，肿瘤和非肿瘤组织可以以62-75%的灵敏度和83-85%的特异性区分。

项目成果

医用画像に基づく計算解剖学の消化器外科領域への応用.

基于医学图像的计算解剖学在胃肠外科领域的应用

• 发表时间: 2013
• 期刊: MEDICAL PHOTONICS
• 作者: 赤星朋比古;富川盛雅，橋爪 誠
• 通讯作者: 富川盛雅，橋爪 誠

IEEE : Objective Skill Evaluation for Laparoscopic Training Based on Motion Analysis

IEEE：基于运动分析的腹腔镜训练客观技能评估

• 发表时间: 2013
• 期刊: IEEE Transaction on Biomedecal Engineering
• 作者: Zhuohua L;Uemura M;Zecca M;IEEE;Sessa S;Member;IEEE;Isii H;Tomikawa M;Hashizume M;Yamaguchi S;Yoshida D;Takanishi A;Member
• 通讯作者: Member

An augmented reality navigation sysytem for pediatric oncologic surgery based on preoperative CT and MRI images

基于术前 CT 和 MRI 图像的小儿肿瘤手术增强现实导航系统

• 发表时间: 2013
• 期刊: Journal of Pediatric Surgery
• 影响因子: 2.4
• 作者: Souzaki R;Ieiri S;Uemura M;Ouchida K;Tomikawa M;Kioshita Y;Koga Y;Suminoe A;Kohashi K;Oda Y;Hara T;Hashizume M;Taguchi T
• 通讯作者: Taguchi T

受講者に対するアンケート結果からみた内視鏡外科手術基本手技トレーニングセミナーの有効性

基于参与者问卷调查结果的基础内窥镜手术培训研讨会的有效性

• 发表时间: 2013
• 作者: 富川盛雅;植村宗則;神代竜一;大内田研宙;赤星朋比古;家入里志;大平猛;田上和夫;橋爪誠
• 通讯作者: 橋爪誠

Image-guided laparoscopic surgery in an open MRI operating theater

• DOI: 10.1007/s00464-012-2737-y
• 发表时间: 2013-01
• 期刊: Surgical Endoscopy
• 作者: N. Tsutsumi;M. Tomikawa;M. Uemura;T. Akahoshi;Y. Nagao;K. Konishi;S. Ieiri;Jaesung Hong;Y. Maehara;M. Hashizume