Development of an integrated endoscopic system based on optical imaging and hyper-spectral data analysis for early gastrointestinal cancer detection

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We examined a possibility of our developed hyper spectral camera system for a diagnosis of colorectal cancer. During the endoscopic screening, hyper spectral camera by which the reflectance spectral data of 400-800nm for 640x480 pixels are captured. All lesions that appeared abnormal and normal mucosa around the lesion were targeted. Resected specimens of primary colorectal cancer and non-neoplastic mucosa were obtained and measured spectrum at several points of the colorectal mucosa. We evaluated accuracy of the ability for tumor detection by the hyper spectral camera system. The average reflection intensity rate of each categories are, normal mucosa; 0.96, hyperplastic polyp; 0.90, adenoma; 0.86 and adenocarcinoma; 0.60. The increased spectral absorption ex vivo at 510nm was observed. Tumor and non-tumor tissue could be discriminated with a sensitivity of 62-75% and a specificity of 83-85% in both in vivo and ex vivo experiment.