Highly-controlled asymmetric environment using chiral metal nanoclusters

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We attained the construction of highly-controlled asymmetric environment utilizing chiral metal nanocluster catalysts we originally developed. Asymmetric 1,4-addition reactions of aromatic boronic acids with nitroolefins were developed and it became clear that a chiral diene with amide moiety could give high enantioselectivity. Furthermore, three reactions (alcohol oxidation with molecular oxygen, formation of unsaturated carbon-carbon bond, and asymmetric 1,4-addition reactions of arylboronic acids with unsaturated carbonyl compounds) were accumulated and these reactions were found to proceed continuously with high selectivities by sequential addition of catalysts and substrates. Analysis of chiral nanocluster catalysts was also performed.