Function of a new splicing factor, RBM4

新剪接因子 RBM4 的功能

• 批准号: DP0664650
• 负责人: Prof Brian Morris
• 金额: $ 20.23万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-03-22 至 2008-12-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664650
• 关键词: Function; new; splicing; factor; RBM4

New genomic knowledge is revolutionizing our world. However our understanding of the basic mechanisms of RNA maturation, especially regulation of splicing lags significantly behind our understanding of related genomic processes. This project is a genetic approach to help elucidate the function of new splicing factors and characterize the way in which specific RNA sequences are recognized. It should promote the better understanding of regulatory events involved in controlling gene expression during development and differentiation. Results from this project will also provide new insights into the 'multifunctionality' of cellular proteins and will illustrate the importance of RNA studies in molecular medicine.

新的基因组知识正在彻底改变我们的世界。然而，我们对RNA成熟的基本机制，特别是剪接的调控的理解远远落后于我们对相关基因组过程的理解。该项目是一种遗传学方法，以帮助阐明新的剪接因子的功能，并表征特定RNA序列被识别的方式。这将有助于更好地理解在发育和分化过程中控制基因表达的调控事件。这个项目的结果也将为细胞蛋白质的“多功能性”提供新的见解，并将说明RNA研究在分子医学中的重要性。