TNF receptor 2 and iNOS genes in basis of cardiovascular disease

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Cardiovascular diseases account for almost half of total deaths in Australia and other industrialized countries. Hypertesnion, coronary artery disease and diabetes are major contributing factors to mortality and morbidity. It is well known that each of these have a genetic basis, as well as having environmental influences. A key focus of reseach internationally is discovery of the molecular mechanisms involved. Our recent findings point to a role for the inducible nitric oxide synthase gene (which generates nitric oxide, a potent blood vessel dilator) and tumor necrosis factor receptor 2 gene (whose product sends signals to the former gene) in heart, kidney and blood vessel diseases. We now propose to find the actual gene changes responsible and the molecules and mechanisms involved. By elucidating roles in cardiovascular physiology and pathology the importance of these for cardiovascular function will be ascertained, and may open up new avenues for treatment.