Molecular mechanism of regulation of human renin mRNA

人肾素mRNA调控的分子机制

• 批准号: DP0559162
• 负责人: Prof Brian Morris
• 金额: $ 25.67万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-03-11 至 2008-03-10
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0559162
• 关键词: Molecular; mechanism; regulation; human; renin

Genetic technologies and genomics research are an international priority likely to reap rich rewards intellectually and commercially. The shrinking of the once-touted gene number to a more modest level has been accompanied by a corresponding increase in the complexity in the protein products arising from each gene, and even more so the methods used by cells to control gene expression. By elucidating the latter for a key gene we will open up new avenues for control of gene expression in various organisms. Devising novel means of chemically modulating stability of specific mRNA molecules will have beneficial implications for health, livestock production and agriculture.

基因技术和基因组研究是一项国际优先事项，可能会在智力和商业上获得丰厚回报。随着曾经被吹捧的基因数量减少到更适度的水平，每个基因产生的蛋白质产物的复杂性也相应增加，细胞用来控制基因表达的方法更是如此。通过阐明后者的关键基因，我们将为控制各种生物的基因表达开辟新的途径。设计新的方法来化学调节特定的mRNA分子的稳定性，将对健康、畜牧业生产和农业产生有益的影响。