Isoflurane inhibits erythropietin induction under hypoxic condition in pap mime

促红细胞生成素（EPO）最初被认为是一种造血生长因子，在中枢神经系统（CNS）中内源性表达。中枢神经系统的EPO在缺氧条件下被诱导，并发挥神经保护作用。小鼠在出生后7天暴露于含0.5%异氟醚或不含0.5%异氟醚的8%氧气中。研究EPO mRNA、caspase-3 mRNA和BDNF mRNA在脑组织中的表达。0.5%异氟醚可显著抑制缺氧诱导的脑组织EPO mRNA表达，诱导BDNF mRNA表达。8%的氧气和0.5%的异氟醚暴露后的小鼠有更大的学习障碍。在8%氧气和0.5%异氟醚暴露前皮下注射EPO（5000单位/公斤）可改善空间记忆/学习。

Erythropoietin (EPO), originally identified as a hematopoietic growth factor produced, is endogenously expressed in the central nervous system (CNS). EPO in the CNS is induced under hypoxic conditions and plays a role in neuroprotection. Mice were exposed to 8 % oxygen with or without 0.5 % isoflurane on postnatal 7day. Expression of EPO mRNA and caspase-3 mRNA and BDNF mRNA in brain was studied. Hypoxia-induced EPO mRNA expression in the brain was significantly suppressed and BDNF mRNA expression was induced by 0.5 % isoflurane. Mice after 8 % oxygen with 0.5 % isoflurane exposure had a greater learning impairment. Subcutaneous injection of EPO (5000 unit/kg) before 8 % oxygen with 0.5 % isoflurane exposure improved spatial memory/learning.