Unified computational modeling of the total human heart function with smoothed particle hydrodynamics

使用平滑粒子流体动力学对人体总体心脏功能进行统一计算建模

• 批准号: 397665284
• 负责人: Privatdozent Dr.-Ing. Xiangyu Hu
• 金额: --
• 依托单位: Lehrstuhl für Aerodynamik und Strömungsmechanik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/397665284?language=en
• 关键词: Unified; computational; modeling; total; human

The heart is one of our most vital and most complex organs. The four chambers and four valves of the heart cooperate closely for filling, ejecting, and the overall pumping function by the interaction of electrical and mechanical (including solids and flow) dynamics.Modeling these dynamics and their coupling is important for understanding these complex phenomena. While the current computational models are able to compute the coupled electrical and solid mechanics or the coupled solid and fluid mechanics, they suffer from serious difficulties on integrating all the three dynamics due to the conflicts between their limited modeling flexibility and the complex physical processes involved. The long-term objective of the current project is to develop a heart simulator with the potential to improve the treatment for heart disease. In the first funding period of 3 years, we achieved fruitful achievements, which represents the substantial progresses towards developing unified SPH-based model for total human heart function. We have also encountered challenges in computationally efficient modeling of the cardiac conduction system and valves, as well as issues with GPU acceleration, but have effectively addressed them in our recent accomplishments.In the second funding period of 3 years, we will continue to work on coupling of cardiac conduction system with muscle activation, modeling of valves and their coupling with fluid dynamics. Then, we will integrate the developed models and algorithms into workstation-based total-function heart simulator, carry out numerical simulations of the total heart function with anatomical high-resolution heart models and explore the possible clinical applications.

心脏是我们最重要、最复杂的器官之一。心脏的四个腔室和四个瓣膜通过电气和机械（包括固体和流动）动力学的相互作用紧密配合，以实现填充、喷射和整体泵送功能。对这些动力学及其耦合进行建模对于理解这些复杂现象非常重要。虽然当前的计算模型能够计算耦合的电气和固体力学或耦合的固体和流体力学，但由于有限的建模灵活性和所涉及的复杂物理过程之间的冲突，它们在整合所有三种动力学方面遇到了严重的困难。当前项目的长期目标是开发一种具有改善心脏病治疗潜力的心脏模拟器。在首个3年的资助期内，我们取得了丰硕的成果，代表着在开发基于SPH的人类心脏全功能统一模型方面取得了实质性进展。我们在心脏传导系统和瓣膜的计算高效建模方面也遇到了挑战，以及GPU加速的问题，但在我们最近的成果中有效地解决了这些问题。在三年的第二个资助期内，我们将继续致力于心脏传导系统与肌肉激活的耦合、瓣膜的建模及其与流体动力学的耦合。然后，我们将开发的模型和算法集成到基于工作站的全功能心脏模拟器中，利用解剖高分辨率心脏模型对全功能心脏模拟器进行数值模拟，并探索可能的临床应用。