Understanding the mechanism of synchronous chromosome segregation that ensures the faithful inheritance of genomic information

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In order to ensure faithful chromosome segregation, cells have to coordinate the dissociation of cohesion and subsequent induction of poleward movement of disjoined sister chromatids. We found that separase inhibited the Cdk1 kinase activity upon its proteolytic activation to facilitate poleward movement of sisters. Thus, by consecutively acting as a protease and a Cdk1 inhibitor, separase coordinates two key processes to ensure faithful chromosome segregation