Creation of novel antimicrobial designed proteins against infectious pathogenic microorganisms

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Antimicrobial peptides(AMPs) are promising antibiotics as they possess strong antimicrobial activity and very broad spectra of activity. We designed a novel AMP. We utilized Candida albicans as a model organism that produces secreted aspartic proteases(Saps) as a virulence attribute. The designed peptide possessed no antimicrobial activity until it was activated by Sap isozymes. Furthermore, it demonstrated selective antimicrobial activity against C. albicans, but not against Saccharomyces cerevisiae.