Inter-relationship analysis of genetic polymorphism of human bitter-taste receptor TAS2R and hepatic detoxification enzyme GSTs

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Epidemiological studies have shown that isothiocyanate compounds in the cruciferous plant prevents cancer incidence rate. If the taster of this bitter compounds by TAS2R, bitter taste receptor, the intake of this compound may decrease due to its too much bitterness sensation during eating. Another possibility is hepatic glutathione S-transferase (GST) polymorphism. The latter one is involved in the detoxification mechanism of isothiocyanate compounds after eating in the liver, i.e., we cannot eat cruciferous plants if the GST activity is low due to its enzyme polymorphism. Therefore, we analyzed the relationship of TAS2Rs and GSTs polymorphism in human volunteer, and intended to clarify the mechanism involved in the individual difference of cruciferous plant acceptability. Up to now, we found that one of the GST isozyme may be involved in this acceptability, and this may be associated with the non-taster of PTC by TAS2R38, though further detailed study is necessary.