The apoptosis suppression effect on brain neuron of plasmalogen

采用定量分析、细胞培养功能评价和动物实验等方法，研究了纤溶酶原对大脑神经元的凋亡抑制作用。细胞培养研究证实了纤溶酶原对细胞凋亡的抑制作用。建立了LC-MS/MS法定量分析食品和生物样品中的纤溶酶原分子种类。对食品中富含DHA的血浆蛋白原进行了筛选。为了阐明其对阿尔茨海默病模型大鼠的神经保护作用，用富含DHA的海菠菜血浆蛋白原对阿尔茨海默病模型大鼠进行治疗。

The apoptosis suppression effect on brain neuron of plasmalogen was studied by using quantitative analysis, the functional assessment with cell culture study and animal study. The cell culture study was proved the apoptosis suppression effect of plasmalogen. The quantitative analysis of plasmalogen molecular species in foods and biosamples usingLC-MS/MS was developed. Food substances were screened for DHA-rich-plasmalogen. DHA-rich-plasmalogen from sea-pineapple was administrated on Alzheimer model rat on the aim to elucidate its neuron protection effect.