The apoptosis suppression effect on brain neuron of plasmalogen

采用定量分析、细胞培养及动物实验的功能评价方法，研究了plasmalogen对脑神经细胞凋亡的抑制作用。细胞培养实验证实了其抑制细胞凋亡的作用。建立了液相色谱-质谱联用技术（lc -MS/MS）定量分析食品和生物样品中等离子体原的方法。筛选食品中富含dha的plasmalogen。采用海凤梨富dha质脲原给药，观察其对老年痴呆模型大鼠神经元的保护作用。

The apoptosis suppression effect on brain neuron of plasmalogen was studied by using quantitative analysis, the functional assessment with cell culture study and animal study. The cell culture study was proved the apoptosis suppression effect of plasmalogen. The quantitative analysis of plasmalogen molecular species in foods and biosamples usingLC-MS/MS was developed. Food substances were screened for DHA-rich-plasmalogen. DHA-rich-plasmalogen from sea-pineapple was administrated on Alzheimer model rat on the aim to elucidate its neuron protection effect.