Oxyfunctionalization through Photoinduced Oxygen Atom Transfer

通过光诱导氧原子转移进行氧功能化

• 批准号: 401007518
• 负责人: Dr. Jola Pospech
• 金额: --
• 依托单位: Nachwuchsgruppe Katalytische Funktionalisierungen
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/401007518?language=en
• 关键词: Oxyfunctionalization; through; Photoinduced; Oxygen; Atom

The research project delineates the development of an organocatalytic oxyfunctionalization reaction through photomediated oxygen atom transfer. Relying on the direct C‒H bond oxygenation via photomediated fragmentation of amine N-oxides, this approach will provide a chemical tool for the direct introduction of an alcohol functionality. The specific aim is to develop an efficient and practicable methodology that allows the direct chemical synthesis of oxygenated pharmacophors, biologically active compounds and xenobiotics that are otherwise accessed via enzymatic routes. Thus, elaborating a methodology for the direct C‒H bond oxygenation via photomediated fragmentation of amine N-oxides would not only address a formidable challenge in organic synthesis, it would simultaneously provide a chemical equivalent to the mammalian arene and alkane monooxygenases.

该研究项目描述了通过光介导氧原子转移进行有机催化氧官能化反应的发展。依靠通过胺 N-氧化物的光介导断裂进行的直接 C-H 键氧化，该方法将为直接引入醇官能团提供化学工具。具体目标是开发一种有效且实用的方法，允许直接化学合成含氧药效团、生物活性化合物和异生素，而这些药物原本可以通过酶促途径获得。因此，通过胺 N-氧化物的光介导断裂来阐述直接 C-H 键氧化的方法不仅可以解决有机合成中的艰巨挑战，还可以同时提供与哺乳动物芳烃和烷烃单加氧酶等效的化学物质。