Development and systematization of telemetering equipments used for coronary hemodynamic in conscious dogs.

为了研究抗心绞痛药物的血流动力学效应，我们研制了一种小型压力遥测仪、基于多普勒原理的血流遥测仪和一种传输时间维度遥测仪，以及它们的无线电接收和解调、信号和数据处理系统。在应用中，我们考察了几种抗心绞痛药物对心外膜大冠状动脉和左心室内径、LVP、LVDP/DT、LVEDP、冠脉流量、血压和数据处理系统的影响舌下含服硝酸甘油5微克/kg可有效增加左回旋支冠状动脉内径，作用持续5~8分钟。而冠脉血流量、心率、血压、左心室内径、LVEDP和LVDP/dt无明显变化。当剂量增加到25微克/公斤时，这些效应基本没有改变。结论：硝酸甘油对心绞痛的主要治疗作用与扩张大冠状动脉有关。

In order to make remote analog and digital recordings of blood pressure, coronary blood flow, diameters of large epicardial coronary artery and of left ventricle and others from unanesthetized and unrestrained dogs for the study on hemodynamic effects of antianginal drugs, we developed a miniature pressure telemeter, blood flow telemeter based on Doppler principle and a transit time dimension telemeter and their radio-receiver and demodulating, signals and deta processing systems.In application, we examined effects of some anti-anginal drugs on diameters of epicardial large coronary artery and left ventricle, LVP, LVdp/dt, LVEDP, coronary blood flow, blood pressure, heart rate and ECG.Sublingual nitroglycerin 5 microgram/kg effectively increased left circumflex coronary diameter, the effect lasted 5-8 minutes. However, coronary blood flow, heart rate, blood pressure, left ventricular diameter, LVEDP and LVdp /dt were not significantly changed. With increasing dose up to 25 microgram/kg, these effects have not changed basically. It is concluded that the prime therapeutic action of nitroglycerin in angina pectoris is related to dilate large coronary arteries.