Development and systematization of telemetering equipments used for coronary hemodynamic in conscious dogs.

用于清醒狗冠状动脉血流动力学遥测设备的开发和系统化。

• 批准号: 60870094
• 负责人: UENO Akira
• 金额: $ 4.99万
• 依托单位: Dept.of Pharmacol, Nagasaki Univ. School of Med.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60870094/
• 关键词: Coronary hemodynamics; Nitroglycerin; Conscious dog; Radiotelemeter; 伝導・抵抗血管; 冠循環; 無麻酔無拘束動物

In order to make remote analog and digital recordings of blood pressure, coronary blood flow, diameters of large epicardial coronary artery and of left ventricle and others from unanesthetized and unrestrained dogs for the study on hemodynamic effects of antianginal drugs, we developed a miniature pressure telemeter, blood flow telemeter based on Doppler principle and a transit time dimension telemeter and their radio-receiver and demodulating, signals and deta processing systems.In application, we examined effects of some anti-anginal drugs on diameters of epicardial large coronary artery and left ventricle, LVP, LVdp/dt, LVEDP, coronary blood flow, blood pressure, heart rate and ECG.Sublingual nitroglycerin 5 microgram/kg effectively increased left circumflex coronary diameter, the effect lasted 5-8 minutes. However, coronary blood flow, heart rate, blood pressure, left ventricular diameter, LVEDP and LVdp /dt were not significantly changed. With increasing dose up to 25 microgram/kg, these effects have not changed basically. It is concluded that the prime therapeutic action of nitroglycerin in angina pectoris is related to dilate large coronary arteries.

为了对未麻醉、不受约束犬的血压、冠状动脉血流量、大心外膜冠状动脉直径和左心室直径等进行远程模拟和数字记录，用于研究抗心绞痛药物的血流动力学作用，我们研制了微型血压遥测仪、基于多普勒原理的血流遥测仪和传输时间维遥测仪及其无线电接收机、解调、信号和数据处理系统。应用中观察了几种抗心绞痛药物对心外膜大冠状动脉直径、左心室直径、LVP、LVdp/dt、LVEDP、冠状动脉血流量、血压、心率和心电图的影响。舌下硝酸甘油5微克/kg有效增加左旋冠状动脉直径，效果持续5 ~ 8分钟。冠状动脉血流量、心率、血压、左室直径、LVEDP、LVdp /dt无明显变化。当剂量增加到25微克/公斤时，这些效应基本没有改变。结论：硝酸甘油对心绞痛的主要治疗作用与扩张冠状动脉有关。

项目成果

A.Ueno and K.Nonaka: "Cardiovascular effects of Nipradilol, a novel <beta> -blocking agent, in unanesthetized and unrestrained dogs." Japanese Journal of Pharmacology. 39. 213-P (1985)

A.Ueno 和 K.Nonaka：“尼普地洛（一种新型 β 受体阻滞剂）对未麻醉和不受约束的狗的心血管作用。”

Kazuko Nonaka: Japanese Journal of Pharmacology. 41. 44-P (1987)

野中和子：日本药理学杂志。

日本臨床生理学会雑誌. 15-増刊号. (1985)

日本临床生理学会杂志 15-特刊（1985 年）。

K.Nonaka;A.Ueno: Japanese Journal of Pharmacology. 40. 51-52 (1986)

K.Nonaka；A.Ueno：日本药理学杂志。

K.Nonaka;A.Ueno: Japanese Journal of Pharmacology. 40. 257-P (1986)

K.Nonaka；A.Ueno：日本药理学杂志。