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Excimer Laser Angioplasty; its Development of the System for Clinical Use.

准分子激光血管成形术；

基本信息

批准号：
62870050
负责人：
UENO Akira
金额：
$ 13.5万
依托单位：
Yamanashi Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1989
项目状态：
已结题

项目摘要

We investigated the potential of excimer laser to apply for the laser angioplasty. The apparatus was constructed by Hamamatsu-Photonicus KK., and excimer lasers used in this study were KrF-excimer(wave length:248nm), XeCl-excimer(wave length:308nm), and XeF-excimer(wave length:351nm). The direct irradiation with KrF- and XeCl-excimer lasers could produced the sharp-edged crater on the normal and also sclerotic aortic specimen with no visible thermal damage, but in case of XeF-excimer laser irradiation the thermal damage was evident in advanced tissue of the crater. The depth of the crater increased in a linear fashion with increasing duration of irradiation, while the width remained constant. Thus, it was revealed that the excimer laser was basically one of the most suitable laser source to the laser angioplasty. However, the excimer laser irradiation through a quartz fiber could produce only a small and shallow crater on the specimen because of the low transmission rate of a fiber(KrF:22%, XeCl:37%, XeF:57%). These results showed that excimer laser angioplasty with these equipments would be inefficient for the clinical usage, and the efforts should be made to develop the more powerful excimer laser delivery system. Considering the difficulties in improving the quartz fiber, the development of a new apparatus with longer pulse oscillation of excimer laser capable of delivering the higher output power will be needed.

本文探讨了准分子激光在激光血管成形术中的应用前景。该装置由Hamamatsu-Photonicus KK.，所用的准分子激光器为KrF准分子激光器（波长248 nm）、XeCl准分子激光器（波长308 nm）和XeF准分子激光器（波长351 nm）。用KrF和XeCl准分子激光直接照射可在正常和硬化的主动脉标本上产生边缘尖锐的火山口，而无可见的热损伤，但在XeF准分子激光照射的情况下，火山口的晚期组织的热损伤是明显的。坑的深度以线性方式增加，随着照射时间的增加，而宽度保持不变。结果表明，准分子激光是激光血管成形术最合适的光源之一。然而，通过石英光纤的准分子激光照射只能产生一个小而浅的弹坑上的试样，因为光纤的低传输率（KrF：22%，XeCl：37%，XeF：57%）。这些结果表明，使用这些设备进行准分子激光血管成形术的临床应用效率低，应努力开发更强大的准分子激光传输系统。考虑到石英光纤在改进方面的困难，需要开发一种新的具有更长脉冲振荡的准分子激光器，能够提供更高的输出功率。