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Development of the characteristic X-ray generator for biological research

开发用于生物研究的特征X射线发生器

基本信息

批准号：
63880023
负责人：
SASAKI Masao
金额：
$ 9.02万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63880023/
关键词：
Characteristic X-ray Soft X-ray X-ray generator Radiation biology 超軟X線

项目摘要

In the research on radiation biology, there is an increasing interest in the use of monochromatic soft X-rays as a probe for the understanding of primary processes of damage fixation. In this study, we have developed a characteristic X-ray generator for the biological research. This has been the first attempt in Japan and the fifth in the world. The machine consisted of X-ray generator, ultra-low voltage power supply and dosimetry system. In 1988, fundamental parts of the irradiation system have been developed, and the irradiation system has been completed in 1989 by installing dosimetry system. Running characteristics, quality and quantity of radiations were examined and applied to the cultured mammalian cells.The machine has a maximum power of 2kW with variable tube voltage of 1-2OkV, which is highly stable even below 5kV. The monitor chamber installed in the flight tube worked accurately while it was newly developed in this study. The radiation field has a very uniform dose distribution with the difference of less than 1%. According to the energy spectrum, the contamination of bremsstralung was about 10% for Cu K X-rays, and less than 1% for Al K X-rays. Dose has been determined by extrapolation chamber. Biological effects was consistent in the repeated experiments for survival of cultured Chinese hamster cells.Dose control and measurement of the ultrasoft X-rays are also still developmental area in the physics. Therefore, the present results may also contribute to the other relevant field. A cooperative study is now being arranged by MRC in UK. It would be expected that such international and domestic cooperative studies using this machine will enhance further development of this research field.

在辐射生物学的研究中，人们越来越感兴趣的是使用单色软X射线作为探针来了解损伤固定的初级过程。在本研究中，我们开发了一种用于生物研究的特征X射线发生器。这是日本的第一次尝试，也是世界上的第五次尝试。该设备由X射线发生器、超低压电源和剂量测量系统组成。1988年，辐照系统的基本部件已经开发出来，1989年通过安装剂量测定系统完成了辐照系统。该装置最大功率2kW，管电压1 ~ 20 kV，在5 kV以下工作稳定。本研究中新研制的监测舱安装在飞行管内，工作准确。辐射场具有非常均匀的剂量分布，其差异小于1%。能谱分析表明，Cu K X射线的韧致辐射污染约为10%，Al K X射线的韧致辐射污染小于1%。已通过外推室确定剂量。在对培养的中国仓鼠细胞的多次存活实验中，生物学效应是一致的，超软X射线的剂量控制和测量也是物理学中的一个发展领域。因此，本研究结果也可能有助于其他相关领域。英国MRC正在安排一项合作研究。希望利用该仪器进行的国际和国内合作研究能促进该研究领域的进一步发展。