Elucidation of regulatory mechanisms of mitochondrial function in failing heart by Tim44 and its therapeutic application.

Tim44 阐明衰竭心脏线粒体功能的调节机制及其治疗应用。

• 批准号: 21K16026
• 负责人: Ikeda Soichiro
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K16026/
• 关键词: 心不全; 心筋リモデリング; ミトコンドリア; 酸化ストレス; 細胞死; ミトコンドリアタンパク取り込み機構

项目成果

Immunomodulatory Cell Therapy Using αGalCer-Pulsed Dendritic Cells Ameliorates Heart Failure in a Murine Dilated Cardiomyopathy Model.

• DOI: 10.1161/circheartfailure.122.009366
• 发表时间: 2022-12
• 期刊: CIRCULATION-HEART FAILURE
• 影响因子: 9.7
• 作者: Ikeda, Masataka;Ide, Tomomi;Matsushima, Shouji;Ikeda, Soichiro;Okabe, Kosuke;Ishikita, Akihito;Tadokoro, Tomonori;Sada, Masashi;Abe, Ko;Sato, Midori;Hanada, Akiko;Arai, Shinobu;Ohtani, Kisho;Nonami, Atsushi;Mizuno, Shinichi;Morimoto, Sachio;Motohashi, Shinichiro;Akashi, Koichi;Taniguchi, Masaru;Tsutsui, Hiroyuki
• 通讯作者: Tsutsui, Hiroyuki

Heart Rate Reduction with Ivabradine Prevents Cardiac Rupture after Myocardial Infarction in Mice

• DOI: 10.1007/s10557-020-07123-5
• 发表时间: 2021-01-07
• 期刊: CARDIOVASCULAR DRUGS AND THERAPY
• 影响因子: 3.4
• 作者: Ikeda, Masataka;Ide, Tomomi;Tsutsui, Hiroyuki
• 通讯作者: Tsutsui, Hiroyuki

GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway

• DOI: 10.1016/j.isci.2021.103517
• 发表时间: 2021-12-17
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Ishikita, Akihito;Matsushima, Shouji;Tsutsui, Hiroyuki
• 通讯作者: Tsutsui, Hiroyuki