Active biological fluids

活性生物体液

• 批准号: 22K14012
• 负责人: Schnyder Simon
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K14012/
• 关键词: simulation; cell cycle; active matter; collective behavior

We have completed a first project in which the cell competition between cell types is studied in detail. For this we extended the model to include programmed cell death (apoptosis) and have it be regulated by the cell cycle. We were then able to study the invasion of one tissue into another as a function of the apoptosis and cell cycle parameters. In particular, we found the invasiveness of a tissue to be enhanced by the ability of cells to resist higher pressures and by lowered apoptotic rates. This was a necessary first step to move towards a better understanding of non-volume conserving fluids by studying cell tissue dynamics. Interestingly, we found that synchronization in the cell division/apoptosis events can emerge, leading to oscillations in pressure and cell-cycle activity.

我们已经完成了第一个项目，其中详细研究了细胞类型之间的细胞竞争。为此，我们扩展了模型，包括程序性细胞死亡（凋亡），并使其受到细胞周期的调节。然后，我们能够研究一种组织侵入另一种组织作为细胞凋亡和细胞周期参数的函数。特别是，我们发现细胞抵抗更高压力的能力和降低的凋亡率会增强组织的侵袭性。这是通过研究细胞组织动力学更好地了解非保容液体的必要的第一步。有趣的是，我们发现细胞分裂/凋亡事件的同步化可以出现，导致压力和细胞周期活动的振荡。

项目成果

Competition between cell types under cell cycle regulation with apoptosis

• DOI: 10.1103/physrevresearch.4.033156
• 发表时间: 2022-08
• 期刊: Physical Review Research
• 影响因子: 4.2
• 作者: Jintao Li;S. Schnyder;M. S. Turner;R. Yamamoto

Cell competition in a hybrid mechanochemical model

混合机械化学模型中的细胞竞争

• 发表时间: 2022
• 作者: Jintao Li;Simon K. Schnyder;Matthew S. Turner;Ryoichi Yamamoto
• 通讯作者: Ryoichi Yamamoto

Role of the Cell Cycle in Collective Cell Dynamics

• DOI: 10.1103/physrevx.11.031025
• 发表时间: 2020-12
• 期刊: Physical Review X
• 影响因子: 12.5
• 作者: Jintao Li;S. Schnyder;M. S. Turner;R. Yamamoto

Cell sorting in Dictyostelium discoideum: modeling and force inference

盘基网柄菌中的细胞分选：建模和力推理

• 发表时间: 2023
• 作者: Masahito Uwamichi;Simon K. Schnyder
• 通讯作者: Simon K. Schnyder