Creation of New Lead Compounds using Natural Resources and Metal Nanoparticle Catalysts

我们成功地发现了前所未有的化学转化，并通过海绵Petrosia(Strongylophora)sp.提取物中存在的物质的一步反应生成了一种新的化合物。天然产物提取物中存在的物质与热处理的乙醇进行化学多样化，生成了一种新的、意想不到的四环溴吡咯-咪唑衍生物RAC-6-OEt-圆柱体A。我们还通过新的反应模式证实了它来自自然生成的(-)-圆柱体A。此外，(-)-二溴甲壳素和4，5-二溴吡咯-2-羧酸以及(-)-圆柱碱A在本属中均为首次报道。并对其可能的反应机理和生物活性进行了研究。结果表明，天然产物提取物中存在的物质的直接化学多样化可能是发现新化合物的一种快速而有用的策略。

We accomplished to discover unprecedented chemical conversion and produce a new compound through a one-step reaction of substances present in the extract of marine sponge Petrosia (Strongylophora) sp.Chemical diversification of the substances present in the natural product extract with heat-treated EtOH produced a new, unexpected tetracyclic bromopyrrole-imidazole derivative, rac-6-OEt-cylindradine A. We also confirmed that it originated from naturally occurring (-)-cylindradine A via a new reaction pattern. Moreover, (-)-dibromophakellin and 4,5-dibromopyrrole-2-carboxylic acid as well as (-)-cylindradine A were reported herein for the first time in this genus. Studies on the possible reaction mechanism and bioactivities were also conducted. The results indicate that the direct chemical diversification of substances present in natural product extracts can be a speedy and useful strategy for the discovery of new compounds.