Metal-, Catalyst-, Light- and Electrolysis-Free Decarboxylative C-H Functionalisation of Heterocycles

杂环的无金属、无催化剂、无光和无电解脱羧 C-H 官能化

• 批准号: 2517886
• 金额: --
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2517886
• 关键词: Metal; Catalyst; Light; Electrolysis; Free

This is a PhD research project in Chemistry. We aim to extend our sustainable methodology to develop scalable, late-stage C-H functionalisations of more pharmaceutically relevant heterocycles. In our proof-of-principle work, we predominantly based our optimisation studies on isoquinolines. In this proposal, we will investigate the C H functionalisations of important classes of heterocycles, which were not the focus of our proof-of-principle study, for example purines and azoles. Full optimisation and substrate scope studies will be carried out on the alkylation, acylation as well as carbamoylation reactions, and gram-scale reactions as well as late-stage C-H functionalisations will also be demonstrated to showcase the scalability and functional group tolerance.This proposal lies within the EPSRC research area of synthetic organic chemistry.

这是一个化学博士研究项目。我们的目标是扩展我们的可持续方法，以开发更多药学相关杂环的可扩展的后期C-H官能化。在我们的原理验证工作中，我们主要基于异喹啉的优化研究。在这个建议中，我们将调查的CH官能化的重要类别的杂环，这不是我们的证明的原则研究的重点，例如嘌呤和唑。我们将对烷基化、酰化和氨甲酰化反应进行全面的优化和底物范围研究，并将展示克级反应以及后期C-H官能化，以展示可扩展性和官能团耐受性。该提案属于EPSRC合成有机化学研究领域。