Metal-, Catalyst-, Light- and Electrolysis-Free Decarboxylative Radical Reactions - Towards a More Sustainable Future

无金属、无催化剂、无光和无电解的脱羧自由基反应 - 迈向更可持续的未来

• 批准号: 2518255
• 金额: --
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2518255
• 关键词: Metal; Catalyst; Light; Electrolysis; Free

This PhD project builds on surprising observations in our laboratories that, contrary to the accepted convention, mild, decarboxylative C-H functionalisation of heterocycles do not require metal, photocatalyst, light, high temperatures nor electrolysis to proceed well. A simple switch of solvent, followed by optimisation, successfully renders the C-H functionalisation of heterocycles metal-, catalyst-, light- and electrolysis-free (MCLE-free). Following these exciting preliminary results, we aim to convince the chemical community that we do not need to continue using toxic/precious/non-sustainable metals and catalysts or wasting precious energy to irradiate/heat/electrolyse these oxidative reactions just because it is the status quo. To achieve this, the aims of the project are to i) develop and showcase a myriad of useful MCLE free decarboxylative-functionalisation reactions which are sustainable, practical, cost-effective, scalable and suitable for late-stage functionalisation, ii) pursue further improvements on sustainability, and iii) showcase, using a case study, its utility for a diverse range of fields.

这个博士项目建立在我们实验室令人惊讶的观察结果的基础上，与公认的惯例相反，杂环的温和脱羧基C-H官能化不需要金属、光催化剂、光、高温或电解就可以很好地进行。简单的溶剂切换，然后优化，成功地使杂环的C-H官能化无金属、无催化剂、无光和无电解(无MCLE)。在这些令人振奋的初步结果之后，我们的目标是让化学界相信，我们不需要继续使用有毒/贵重/不可持续的金属和催化剂，也不需要浪费宝贵的能源来照射/加热/电解这些氧化反应，因为这是现状。为了实现这一目标，该项目的目标是：i)开发和展示大量可持续的、实用的、成本效益高的、可扩展的、适合后期功能化的、不含MCLE的有用的脱羧基功能化反应；ii)寻求可持续性方面的进一步改进；以及iii)通过案例研究，展示其在不同领域的效用。