Herbal teas rich in polyphenols for protective modulation of initial oral bioadhesion

富含多酚的花草茶可保护性调节初始口腔生物粘附

• 批准号: 405985440
• 负责人: Professor Dr. Christian Hannig
• 金额: --
• 依托单位: Professur für Spezielle Lebensmittelchemie und Lebensmittelproduktion
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/405985440?language=en
• 关键词: Herbal; teas; rich; polyphenols; protective

The pellicle is the initial protein and glycoprotein-layer which is formed almost instantaneously on all surfaces exposed to the oral fluids. It has protective properties and modulates bacterial colonization and therewith initiation and progression of caries and erosive mineral loss. Optimal prevention of caries and erosions is still a considerable challenge despite the high prevalence of these diseases due to modern diet. In this context innovative biological concepts of high bio-compatibility and sustainability are of increasing relevance. One approach are herbal drugs rich in polyphenols and their components. It has been shown that some herbal extracts modify the ultrastructure of the pellicle yielding a thicker and more electron dense layer. Therewith the protection against erosive noxae is optimized. The aim of the present project is to characterize officinal polyphenolic plant extracts systematically that have not been adopted in preventive dentistry until now. This applies for composition as well as for the impact on bioadhesion-processes and pellicle formation. Thereby, effective plant extracts and plant components will be identified. In a second step, new and simple concepts for preventive dentistry will be developed.

颗粒是初始蛋白质和糖蛋白层，几乎在暴露于口服液体的所有表面上形成。它具有保护特性并调节细菌定植，从而陈述和龋齿的发展和侵蚀性矿物质损失。尽管由于现代饮食而引起的这些疾病的流行率很高，但对龋齿和侵蚀的最佳预防仍然是一个巨大的挑战。在这种情况下，高生物兼容和可持续性的创新生物学概念具有越来越多的相关性。一种方法是富含多酚及其成分的草药。已经表明，一些草药提取物改变了膜的超微结构，产生了更厚，更厚的电子密集层。因此，对侵蚀性Noxae的保护进行了优化。本项目的目的是系统地对预防牙科中尚未采用的多酚植物提取物进行表征。这适用于组成以及对生物粘附过程和颗粒形成的影响。因此，将确定有效的植物提取物和植物成分。在第二步中，将开发用于预防牙科的新的简单概念。

项目成果

Effect of fragaria vesca, hamamelis and tormentil on the initial bacterial colonization in situ.

草莓、金缕梅和托门提尔对细菌原位初始定植的影响

• DOI: 10.1016/j.archoralbio.2020.104853
• 发表时间: 2020
• 期刊: Archives of oral biology
• 影响因子: 3
• 作者: Kirsch J;Jung A;Hille K;König B;Hannig C;Kölling-Speer I;Speer K;Hannig M
• 通讯作者: Hannig M