Herbal teas rich in polyphenols for protective modulation of initial oral bioadhesion

富含多酚的花草茶可保护性调节初始口腔生物粘附

• 批准号: 405985440
• 负责人: Professor Dr. Christian Hannig
• 金额: --
• 依托单位: Professur für Spezielle Lebensmittelchemie und Lebensmittelproduktion
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/405985440?language=en
• 关键词: Herbal; teas; rich; polyphenols; protective

The pellicle is the initial protein and glycoprotein-layer which is formed almost instantaneously on all surfaces exposed to the oral fluids. It has protective properties and modulates bacterial colonization and therewith initiation and progression of caries and erosive mineral loss. Optimal prevention of caries and erosions is still a considerable challenge despite the high prevalence of these diseases due to modern diet. In this context innovative biological concepts of high bio-compatibility and sustainability are of increasing relevance. One approach are herbal drugs rich in polyphenols and their components. It has been shown that some herbal extracts modify the ultrastructure of the pellicle yielding a thicker and more electron dense layer. Therewith the protection against erosive noxae is optimized. The aim of the present project is to characterize officinal polyphenolic plant extracts systematically that have not been adopted in preventive dentistry until now. This applies for composition as well as for the impact on bioadhesion-processes and pellicle formation. Thereby, effective plant extracts and plant components will be identified. In a second step, new and simple concepts for preventive dentistry will be developed.

薄膜是最初的蛋白质和糖蛋白层，其几乎在暴露于口腔流体的所有表面上瞬间形成。它具有保护特性并调节细菌定植，从而引发和发展龋齿和侵蚀性矿物质损失。尽管由于现代饮食，龋齿和糜烂的患病率很高，但最佳预防龋齿和糜烂仍然是一个相当大的挑战。在这种情况下，具有高生物相容性和可持续性的创新生物概念越来越重要。一种方法是富含多酚及其成分的草药。它已被证明，一些草药提取物修改超微结构的表膜产生更厚和更电子致密层。因此，针对侵蚀性NOx的保护被优化。本项目的目的是系统地描述迄今为止尚未在预防牙科学中采用的药用多酚植物提取物。这适用于组合物以及对生物粘附过程和薄膜形成的影响。因此，将鉴定有效的植物提取物和植物组分。在第二步中，将开发预防牙科的新的和简单的概念。

项目成果

Effect of fragaria vesca, hamamelis and tormentil on the initial bacterial colonization in situ.

草莓、金缕梅和托门提尔对细菌原位初始定植的影响

• DOI: 10.1016/j.archoralbio.2020.104853
• 发表时间: 2020
• 期刊: Archives of oral biology
• 影响因子: 3
• 作者: Kirsch J;Jung A;Hille K;König B;Hannig C;Kölling-Speer I;Speer K;Hannig M
• 通讯作者: Hannig M