Herbal teas rich in polyphenols for protective modulation of initial oral bioadhesion

膜是最初的蛋白质和糖蛋白层，几乎是瞬间在所有接触口腔液的表面形成的。它具有保护特性，并调节细菌定植，从而引发和发展龋齿和侵蚀性矿物质损失。尽管由于现代饮食，龋齿和糜烂的患病率很高，但最佳预防仍然是一个相当大的挑战。在这种情况下，高生物相容性和可持续性的创新生物学概念越来越重要。一种方法是使用富含多酚及其成分的草药。研究表明，一些草药提取物可以改变细胞膜的超微结构，使细胞膜变得更厚，电子密度更高。从而优化了对侵蚀菌的防护。本项目的目的是表征迄今为止尚未在预防性牙科中采用的药用多酚植物提取物系统。这适用于组合物以及对生物粘附过程和膜形成的影响。因此，有效的植物提取物和植物成分将被识别。在第二步，新的和简单的概念预防牙科将发展。

The pellicle is the initial protein and glycoprotein-layer which is formed almost instantaneously on all surfaces exposed to the oral fluids. It has protective properties and modulates bacterial colonization and therewith initiation and progression of caries and erosive mineral loss. Optimal prevention of caries and erosions is still a considerable challenge despite the high prevalence of these diseases due to modern diet. In this context innovative biological concepts of high bio-compatibility and sustainability are of increasing relevance. One approach are herbal drugs rich in polyphenols and their components. It has been shown that some herbal extracts modify the ultrastructure of the pellicle yielding a thicker and more electron dense layer. Therewith the protection against erosive noxae is optimized. The aim of the present project is to characterize officinal polyphenolic plant extracts systematically that have not been adopted in preventive dentistry until now. This applies for composition as well as for the impact on bioadhesion-processes and pellicle formation. Thereby, effective plant extracts and plant components will be identified. In a second step, new and simple concepts for preventive dentistry will be developed.