Antifouling surfaces with spatially alternating interfacial properties

具有空间交替界面特性的防污表面

• 批准号: 403577877
• 负责人: Professor Dr. Christian Hannig
• 金额: --
• 依托单位: Leibniz-Institut für Polymerforschung Dresden (IPF)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/403577877?language=en
• 关键词: Antifouling; surfaces; spatially; alternating; interfacial

The proposed project aims at generating a comprehensive understanding of bio-adhesion processes at surfaces with spatially alternating physico-chemical interfacial properties: that is, with periodic structures or alternating surface free energies or alternating elasticities, covering lateral dimensions from the micro- to the nano-scale. Respective substrates will be fabricated in two ways: I. polymer moldings of master structures with and without backfilled cavities by a second polymer phase (= flat and structured, respectively), and II. polished polymer matrices embedded with functionalized silica particles (= flat). The bio-adhesive properties of the substrates, i.e. biomolecule adsorption and bacterial surface colonization, will first be tested using high throughput in vitro assays. Surfaces with low bio-adhesion will subsequently be tested in situ within the human oral cavity to clarify their applicability under realistic and clinically relevant fouling conditions. It is expected that the periodicity of the alternating physico-chemical interfacial properties strongly affects both the kinetics and the strength of bio-adhesion processes: Microscale periodicity might affect bacterial surface colonization directly whereas submicro- to nano-scale dimensions might influence bacterial surface colonization indirectly through the altered adsorption of biomolecules, such as proteins. Furthermore, it is expected that substrates with alternating surface free energies and elasticities will reveal similar trends to structured substrates. Based on the findings, we intend to project a roadmap for the fabrication of tailor-made anti-bioadhesive surfaces, such as coatings for dental restorative materials and implants.

拟议的项目旨在全面了解具有空间交替物理化学界面特性的表面上的生物粘附过程：即具有周期性结构或交替表面自由能或交替弹性，涵盖从微观到纳米尺度的横向维度。各自的基材将以两种方式制造：I.主结构的聚合物成型，有和没有回填腔，通过第二聚合物相（分别=平坦和结构化）；嵌入功能化二氧化硅颗粒（=平面）的抛光聚合物基质。底物的生物粘附特性，即生物分子吸附和细菌表面定植，将首先使用高通量体外试验进行测试。低生物粘附表面随后将在人类口腔内进行原位测试，以阐明其在现实和临床相关污染条件下的适用性。预计交替的物理化学界面性质的周期性强烈影响动力学和生物粘附过程的强度：微尺度的周期性可能直接影响细菌的表面定植，而亚微米到纳米尺度的尺寸可能通过改变生物分子（如蛋白质）的吸附间接影响细菌的表面定植。此外，预计具有表面自由能和弹性交替的衬底将显示出与结构衬底相似的趋势。基于这些发现，我们打算为定制的抗生物粘合剂表面的制造制定一个路线图，例如牙齿修复材料和种植体的涂层。