Regulation of matrix metalloprotease activity during proteolytic invasion of human macrophages (B13*)

人巨噬细胞蛋白水解入侵过程中基质金属蛋白酶活性的调节 (B13*)

• 批准号: 406429021
• 金额: --
• 依托单位: Institut für Medizinische Mikrobiologie, Virologie und Hygiene
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406429021?language=en
• 关键词: Regulation; matrix; metalloprotease; activity; during

The project studies the role of matrix metalloproteases (MMPs) in the proteolytic invasion of macrophages. Within cells, MMPs travel bidirectionally along microtubules, regulated by specific kinesin and dynein motor proteins and members of the RabGTPase family. A novel kinesin regulator of MMP-dependent extracellular matrix proteolysis was discovered. The role of this kinesin in the recycling pathways of MT1-MMP will be studied. Inhibitory peptides are developed and tested for modulation of macrophage invasion in a pathophysiologically relevant context.

该项目研究基质金属蛋白酶(MMPs)在巨噬细胞蛋白水解性侵袭中的作用。在细胞内，基质金属蛋白沿微管双向运动，受特定的动蛋白和动力蛋白马达蛋白和RabGTP酶家族成员的调节。发现了一种新的依赖于基质金属蛋白酶的细胞外基质蛋白分解的激动素调节剂。该激动素在MT1-基质金属蛋白酶循环途径中的作用将被研究。抑制肽的开发和测试是为了在病理生理学背景下调节巨噬细胞的侵袭。