The role of microtubule detyrosination in dendritic structure and function (B12*)

微管脱酪氨酸在树突结构和功能中的作用 (B12*)

• 批准号: 406428837
• 金额: --
• 依托单位: Institut für Biologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406428837?language=en
• 关键词: role; microtubule; detyrosination; dendritic; structure

The project analyzes the microtubule (MT) cytoskeleton and its role in neuronal trafficking. Tyrosination and detyrosination regulate the functionality of MTs. The project aims to understand the role of MT detyrosination in the organization of the cytoskeleton in apical dendrites of pyramidal neurons. It will focus on the role of calpain in the regulation of tubulin tyrosine carboxypeptidase of the vasohibin/chaperone complex. The project will unravel how tubulin detyrosination can regulate the neuronal cytoskeleton, which is relevant for neurodegenerative disorders.

该项目分析了微管（MT）细胞骨架及其在神经元运输中的作用。酪氨酸化和去酪氨酸化调节MT的功能。该项目旨在了解MT去酪氨酸在锥体神经元顶树突细胞骨架组织中的作用。它将集中在钙蛋白酶在调节微管蛋白酪氨酸羧肽酶的血管收缩素/伴侣复合物的作用。该项目将揭示微管蛋白去酪氨酸如何调节神经元细胞骨架，这与神经退行性疾病有关。