Decoding microtubule remodelling in sperm production
Decoding microtubule remodelling in sperm production
批准号:
DP240100815
负责人:
Prof Moira O'Bryan
金额:
$46.86万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2024
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2024-01-01 至 2026-12-31
中文摘要
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英文摘要
All eukaryotic cells possess a dynamic microtubule (MT) cytoskeleton, which requires constant remodelling to satisfy its many essential cellular roles. Emerging data suggests modifications to the MT surface (the tubulin code) may act as instructional signposts for remodelling. This project aims to define a fundamental component of the tubulin code, glutamylation, and define how this directs MT severing. It also aims to define the cellular functions of MT-severing enzyme FIGNL1 and key MT glutamylation enzymes (CCP1, CCP5 and TTLL1). Insights will be generated using sperm production as a model system and will thus inform the mechanisms by which fertile sperm are built, in addition to being relevant to cell biology across eukaryotic species.
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依托单位:
国内基金
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