CXC chemokine receptors and regulation of platelet function, thrombo-inflammation and myocardial remodelling in I/R (B01)

I/R 中的 CXC 趋化因子受体和血小板功能、血栓炎症和心肌重塑的调节 (B01)

• 批准号: 406446267
• 金额: --
• 依托单位: I. Medizinische Klinik: Kardiologie, Angiologie, Pneumologie, Intensivmedizin
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/406446267?language=en
• 关键词: CXC; chemokine; receptors; regulation; platelet

We want to analyse the CXCR4/ACKR3 interplay as well as identify the ACKR3 interactome and underlying signalling pathways for platelet function. Mouse experiments will focus on the influence of comorbidities in myocardial infarction and the impact of platelets on thrombo-inflammation and ventricular remodelling following ischaemia/reperfusion (I/R) of the heart. The experimental research will be complemented by studying the role of CXCR4/ACKR3 in humans with acute myocardial infarction. The translational aspect of the project will be to define ACKR3 as potential therapeutic target in I/R.

我们想要分析 CXCR4/ACKR3 相互作用，并确定 ACKR3 相互作用组和血小板功能的潜在信号通路。小鼠实验将重点关注心肌梗塞合并症的影响以及血小板对心脏缺血/再灌注（I/R）后血栓炎症和心室重塑的影响。该实验研究将通过研究 CXCR4/ACKR3 在人类急性心肌梗塞中的作用来补充。该项目的转化方面将是将 ACKR3 定义为 I/R 的潜在治疗靶点。