Modulation of orthodontic tooth movement though diet and electrolyte metabolism

尽管饮食和电解质代谢影响正畸牙齿移动的调节

基本信息

项目摘要

For orthodontic tooth movement, a mechanical force is applied to a tooth creating pressure and tension zones in the periodontal ligament (PDL), where bone resorption and bone apposition processes take place, thus enabling tooth movement in the direction of force. Despite the importance of orthodontic treatment for patient health, many aspects are yet poorly understood. Since tooth movement is a sterile-inflammatory, immunological process, there are many potential systemic and exogenous influences. In our own preliminary work, the effect of various exogenous modulators on orthodontic tooth movement has already been investigated (strontium ranelate, nicotine, meloxicam). In addition to pharmaceuticals, modulation is also to be expected by certain lifestyle habits such as diet. Among other things, electrolytes such as sodium and potassium are generally consumed in today's society at high, unphysiological quantities as a dietary supplement (for example in finished products). They can therefore exert pharmacological-immunological effects via the electrolyte balance and their local tissue concentration. In our own preliminary work we could show that Na+-rich nutrition leads to Na+ deposition in the skin, which is accompanied by macrophage infiltration. These increasingly express the transcription factor NFAT5 (increased transcription of osmoprotective genes). In preliminary experiments, an increased Na+ concentration in hPDL fibroblasts led to an induction of NFAT5 and genes regarding the remodeling of the extracellular matrix and the RANKL / OPG system. Due to the direct influence of Na+ on the activity of immune cells such as macrophages and hPDL fibroblasts, it can be assumed that the local NaCl concentration in the periodontium could also have an influence on the sterile inflammatory reaction induced by orthodontic tooth movement. However, the role of immunomodulatory properties of electrolytes in this regard has not been studied to date. NaCl could therefore cause an unexpected acceleration or inhibition of orthodontic tooth movement, but also an increase or decrease of undesired associated tooth root resorption, periodontal bone loss or early relapse of the moved teeth towards the initial position. In addition to formulating first preventive recommendations for salt consumption during orthodontic therapy, the exploration of these relationships may also allow targeted use of NaCl as an adjuvant therapeutic. The aim of the proposed project is therefore to investigate the effects of a NaCl-rich / poor diet on orthodontic tooth movement and associated side effects as well as the underlying molecular processes, in particular a possible regulation via NFAT5.
对于正畸牙齿移动,将机械力施加到牙齿上,在牙周膜(PDL)中产生压力和张力区,其中发生骨吸收和骨附着过程,从而使牙齿能够沿力的方向移动。尽管正畸治疗对患者健康的重要性,但许多方面仍知之甚少。由于牙齿移动是一个无菌炎症,免疫过程,有许多潜在的全身和外源性影响。在我们自己的初步工作中,已经研究了各种外源性调节剂对正畸牙齿移动的影响(雷奈酸锶、尼古丁、美洛昔康)。除药物外,某些生活习惯(如饮食)也可进行调节。除此之外,电解质如钠和钾在当今社会中通常以高的非生理量作为膳食补充剂(例如在成品中)消耗。因此,它们可以通过电解质平衡和局部组织浓度发挥药理免疫作用。在我们自己的初步工作中,我们可以表明富含Na+的营养导致皮肤中的Na+沉积,这伴随着巨噬细胞浸润。这些细胞越来越多地表达转录因子NFAT 5(增加的保护性基因的转录)。在初步实验中,hPDL成纤维细胞中Na+浓度的增加导致NFAT 5和与细胞外基质和RANKL / OPG系统重塑相关的基因的诱导。由于Na+对免疫细胞如巨噬细胞和hPDL成纤维细胞的活性的直接影响,可以假设牙周组织中的局部NaCl浓度也可以对正畸牙齿移动引起的无菌炎症反应产生影响。然而,迄今为止尚未研究电解质的免疫调节特性在这方面的作用。因此,NaCl可能导致正畸牙齿移动的意外加速或抑制,但也会增加或减少不期望的相关牙根吸收、牙周骨损失或移动的牙齿向初始位置的早期复发。除了在正畸治疗期间制定盐消耗的第一预防性建议外,这些关系的探索也可能允许有针对性地使用NaCl作为辅助治疗。因此,拟议项目的目的是调查NaCl丰富/贫乏饮食对正畸牙齿移动的影响和相关的副作用以及潜在的分子过程,特别是通过NFAT 5的可能调节。

项目成果

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Privatdozent Dr. Christian Kirschneck其他文献

Privatdozent Dr. Christian Kirschneck的其他文献

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{{ truncateString('Privatdozent Dr. Christian Kirschneck', 18)}}的其他基金

The role of mechanotransductively-induced HIF1α stabilization for the regulation of orthodontic tooth movement
机械传导诱导的 HIF1α 稳定在正畸牙齿移动调节中的作用
  • 批准号:
    318600394
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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