Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

将基于动物的振动力研究加速正畸牙齿移动的剂量分析转化为临床

• 批准号: 10596536
• 负责人: JIE CHEN
• 金额: $ 45.4万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596536
• 关键词: Acceleration; Ally; Animals; Biological; Biomechanics; Bone Density; Canis familiaris; Clinic; Clinical; Clinical Research; Clinical Trials; Devices; Dose; Elements; Ensure; Frequencies; Future; Goals; Human; Iatrogenesis; Individual; Investigation; Litigation; Mature Bone; Mediating; Methods; Modeling; Movement; Orthodontic; Orthodontic Appliances; Outcome; Patients; Pattern; Periodontal Ligament; Phase; Positioning Attribute; Rattus; Reaction; Relapse; Reporting; Root Resorption; Specific qualifier value; Stress; System; Technology; Testing; Time; Tooth Movement; Tooth structure; Traction; Translating; Work; alveolar bone; bone; clinical application; new technology; novel; relapse prevention; response; scale up; side effect; theories; vibration

Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic ABSTRACT Controlled Differential Tooth Movement (CDTM) refers to the ability to move teeth to be displaced faster, or to minimize the movement of teeth to be stationary (i.e., anchorage teeth or teeth during the retention phase). CDTM is highly desired in common orthodontic treatments such as canine retraction, canine impaction, molar protraction, and space closure. Successful CDTM drastically shortens treatment time and reduces common side- effects such as root resorption and anchorage loss. Studies show that an intermittent vibration force (IVF) superimposed on orthodontic force accelerates tooth movement. Further, in the absence of orthodontic force, IVF strengthens bone mineral density of the alveolar bone. However, currently there is little evidence to facilitate optimal selection of stimulation level. Furthermore, lack of control on stimulation level on the target tooth inevitably results in inconsistent reporting of outcomes. The overarching goal of the proposed work is to enable CDTM in the clinic by transitioning from successful animal studies to clinical applications. Objectives of the proposed project include: 1) identifying optimal IVF stimulation level for accelerating orthodontic tooth movement in rats as well as associated side-effects; 2) verifying effects of IVF on bone strengthening resulting in tooth stabilization; and 3) determining the threshold that can be used to scale stimulation level up for larger species like dogs and humans. We hypothesize that: (H1) there is an optimal level of IVF that accelerates movement of targeted teeth without side-effects; (H2) the same IVF can strengthen the bone surrounding the tooth without orthodontic force and reduce relapse during retention; and (H3) stress in the periodontal ligament (PDL) can be used as the threshold to effectively scale up the stimulation level from rats to larger species for achieving accelerated tooth movement. These hypotheses will be tested through three specific aims. Aim 1: Determine the optimal level of IVF (OLIVF) stimulation superimposed on an orthodontic load system that accelerates tooth movement in a rat model (H1) and the associated biological responses. Aim 2: Determine the effects of OLIVF on the tooth without orthodontic force (H2). Aim 3: Scale up stimulation level for larger species including dogs and humans, by normalizing to stress in the PDL, and validate the theory on dogs (H3). A PDL stress threshold will be used as the criterion for scaling up IVF from rats to dogs in this proposed study, with an eye toward scaling up to humans in future studies. Thus, a novel method to ensure delivery of the specified IVF on each individual tooth in the clinic will also be tested. This comprehensive study will pave the way for clinical trials using this technology. Further, associated biomechanics and biological studies will elucidate the mechanism behind IVF based CDTM, which will further advance the field as well as methods for applying this technology.

基于振动力的正畸牙齿加速平移动物实验剂量分析 诊所移动 摘要 受控差异牙齿移动（CDTM）是指移动牙齿以更快地移位的能力，或 为了最小化牙齿静止的运动（即，固定牙齿或保持阶段的牙齿）。 CDTM在常见的正畸治疗中是非常需要的，例如犬齿牵开、犬齿嵌塞、磨牙嵌塞等。 延长和空间闭合。成功的CDTM大大缩短了治疗时间，减少了常见的副作用- 影响，如根吸收和锚固损失。研究表明，间歇振动力（IVF） 叠加正畸力加速牙齿移动。此外，在没有正畸力的情况下， IVF增强牙槽骨的骨矿物质密度。然而，目前几乎没有证据表明， 刺激水平的最佳选择。此外，缺乏对目标牙齿上的刺激水平的控制 不可避免地导致结果报告的不一致。拟议工作的总体目标是， 通过从成功的动物研究过渡到临床应用，将CDTM应用于临床。目标 建议的项目包括：1）确定加速正畸牙齿移动的最佳IVF刺激水平 在大鼠以及相关的副作用; 2）验证IVF对骨强化的影响，导致牙齿 稳定化;以及3）确定可用于针对较大物种按比例增加刺激水平的阈值 就像狗和人一样我们假设：（H1）有一个最佳水平的IVF，加速运动， 目标牙齿没有副作用;（H2）同样的IVF可以加强牙齿周围的骨骼， 正畸力和减少复发期间保持;和（H3）在牙周膜（PDL）的应力可以 用作阈值，以有效地将刺激水平从大鼠扩大到更大的物种， 加速牙齿移动。这些假设将通过三个具体目标进行检验。目标1：确定 体外受精（OLIVF）刺激最佳水平叠加在正畸加载系统上， 大鼠模型（H1）中的运动和相关的生物学反应。目标2：确定OLIVF的效果 在牙齿上没有正畸力（H2）。目的3：扩大包括犬在内的较大种属的刺激水平 和人类，通过对PDL中的压力进行归一化，并在狗身上验证该理论（H3）。PDL应力阈值 在这项拟议的研究中，将用作将IVF从大鼠扩大到狗的标准，着眼于扩大规模 人类在未来的研究中。因此，一种新的方法，以确保交付指定的试管婴儿对每个人 在诊所的牙齿也将进行测试。这项全面的研究将为临床试验铺平道路， 技术.此外，相关的生物力学和生物学研究将阐明IVF背后的机制 的CDTM，这将进一步推进该领域以及应用该技术的方法。