Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

将基于动物的振动力研究加速正畸牙齿移动的剂量分析转化为临床

基本信息

  • 批准号:
    10596536
  • 负责人:
  • 金额:
    $ 45.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-04-01 至 2027-03-31
  • 项目状态:
    未结题

项目摘要

Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic ABSTRACT Controlled Differential Tooth Movement (CDTM) refers to the ability to move teeth to be displaced faster, or to minimize the movement of teeth to be stationary (i.e., anchorage teeth or teeth during the retention phase). CDTM is highly desired in common orthodontic treatments such as canine retraction, canine impaction, molar protraction, and space closure. Successful CDTM drastically shortens treatment time and reduces common side- effects such as root resorption and anchorage loss. Studies show that an intermittent vibration force (IVF) superimposed on orthodontic force accelerates tooth movement. Further, in the absence of orthodontic force, IVF strengthens bone mineral density of the alveolar bone. However, currently there is little evidence to facilitate optimal selection of stimulation level. Furthermore, lack of control on stimulation level on the target tooth inevitably results in inconsistent reporting of outcomes. The overarching goal of the proposed work is to enable CDTM in the clinic by transitioning from successful animal studies to clinical applications. Objectives of the proposed project include: 1) identifying optimal IVF stimulation level for accelerating orthodontic tooth movement in rats as well as associated side-effects; 2) verifying effects of IVF on bone strengthening resulting in tooth stabilization; and 3) determining the threshold that can be used to scale stimulation level up for larger species like dogs and humans. We hypothesize that: (H1) there is an optimal level of IVF that accelerates movement of targeted teeth without side-effects; (H2) the same IVF can strengthen the bone surrounding the tooth without orthodontic force and reduce relapse during retention; and (H3) stress in the periodontal ligament (PDL) can be used as the threshold to effectively scale up the stimulation level from rats to larger species for achieving accelerated tooth movement. These hypotheses will be tested through three specific aims. Aim 1: Determine the optimal level of IVF (OLIVF) stimulation superimposed on an orthodontic load system that accelerates tooth movement in a rat model (H1) and the associated biological responses. Aim 2: Determine the effects of OLIVF on the tooth without orthodontic force (H2). Aim 3: Scale up stimulation level for larger species including dogs and humans, by normalizing to stress in the PDL, and validate the theory on dogs (H3). A PDL stress threshold will be used as the criterion for scaling up IVF from rats to dogs in this proposed study, with an eye toward scaling up to humans in future studies. Thus, a novel method to ensure delivery of the specified IVF on each individual tooth in the clinic will also be tested. This comprehensive study will pave the way for clinical trials using this technology. Further, associated biomechanics and biological studies will elucidate the mechanism behind IVF based CDTM, which will further advance the field as well as methods for applying this technology.
加速正畸牙的动物振动力转换研究的剂量分析

项目成果

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JIE CHEN其他文献

JIE CHEN的其他文献

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{{ truncateString('JIE CHEN', 18)}}的其他基金

Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic
将基于动物的振动力研究加速正畸牙齿移动的剂量分析转化为临床
  • 批准号:
    10362972
  • 财政年份:
    2022
  • 资助金额:
    $ 45.4万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    7799134
  • 财政年份:
    2009
  • 资助金额:
    $ 45.4万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    8020947
  • 财政年份:
    2009
  • 资助金额:
    $ 45.4万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    8220980
  • 财政年份:
    2009
  • 资助金额:
    $ 45.4万
  • 项目类别:
Evaluation of Canine Retraction Strategies
犬类回缩策略的评估
  • 批准号:
    7650664
  • 财政年份:
    2009
  • 资助金额:
    $ 45.4万
  • 项目类别:
Development of Force Based Orthodontic Appliances
基于力的正畸矫治器的开发
  • 批准号:
    7106950
  • 财政年份:
    2006
  • 资助金额:
    $ 45.4万
  • 项目类别:
FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
FRAP 和雷帕霉素敏感信号通路
  • 批准号:
    2877671
  • 财政年份:
    1998
  • 资助金额:
    $ 45.4万
  • 项目类别:
FINITE ELEMENT ANALYSIS OF HUMAN MANDIBLE W/ & W/OUT IMPLANT
人下颌骨的有限元分析
  • 批准号:
    5225403
  • 财政年份:
  • 资助金额:
    $ 45.4万
  • 项目类别:

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