Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

将基于动物的振动力研究加速正畸牙齿移动的剂量分析转化为临床

• 批准号: 10596536
• 负责人: JIE CHEN
• 金额: $ 45.4万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596536
• 关键词: Acceleration; Ally; Animals; Biological; Biomechanics; Bone Density; Canis familiaris; Clinic; Clinical; Clinical Research; Clinical Trials; Devices; Dose; Elements; Ensure; Frequencies; Future; Goals; Human; Iatrogenesis; Individual; Investigation; Litigation; Mature Bone; Mediating; Methods; Modeling; Movement; Orthodontic; Orthodontic Appliances; Outcome; Patients; Pattern; Periodontal Ligament; Phase; Positioning Attribute; Rattus; Reaction; Relapse; Reporting; Root Resorption; Specific qualifier value; Stress; System; Technology; Testing; Time; Tooth Movement; Tooth structure; Traction; Translating; Work; alveolar bone; bone; clinical application; new technology; novel; relapse prevention; response; scale up; side effect; theories; vibration

Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic ABSTRACT Controlled Differential Tooth Movement (CDTM) refers to the ability to move teeth to be displaced faster, or to minimize the movement of teeth to be stationary (i.e., anchorage teeth or teeth during the retention phase). CDTM is highly desired in common orthodontic treatments such as canine retraction, canine impaction, molar protraction, and space closure. Successful CDTM drastically shortens treatment time and reduces common side- effects such as root resorption and anchorage loss. Studies show that an intermittent vibration force (IVF) superimposed on orthodontic force accelerates tooth movement. Further, in the absence of orthodontic force, IVF strengthens bone mineral density of the alveolar bone. However, currently there is little evidence to facilitate optimal selection of stimulation level. Furthermore, lack of control on stimulation level on the target tooth inevitably results in inconsistent reporting of outcomes. The overarching goal of the proposed work is to enable CDTM in the clinic by transitioning from successful animal studies to clinical applications. Objectives of the proposed project include: 1) identifying optimal IVF stimulation level for accelerating orthodontic tooth movement in rats as well as associated side-effects; 2) verifying effects of IVF on bone strengthening resulting in tooth stabilization; and 3) determining the threshold that can be used to scale stimulation level up for larger species like dogs and humans. We hypothesize that: (H1) there is an optimal level of IVF that accelerates movement of targeted teeth without side-effects; (H2) the same IVF can strengthen the bone surrounding the tooth without orthodontic force and reduce relapse during retention; and (H3) stress in the periodontal ligament (PDL) can be used as the threshold to effectively scale up the stimulation level from rats to larger species for achieving accelerated tooth movement. These hypotheses will be tested through three specific aims. Aim 1: Determine the optimal level of IVF (OLIVF) stimulation superimposed on an orthodontic load system that accelerates tooth movement in a rat model (H1) and the associated biological responses. Aim 2: Determine the effects of OLIVF on the tooth without orthodontic force (H2). Aim 3: Scale up stimulation level for larger species including dogs and humans, by normalizing to stress in the PDL, and validate the theory on dogs (H3). A PDL stress threshold will be used as the criterion for scaling up IVF from rats to dogs in this proposed study, with an eye toward scaling up to humans in future studies. Thus, a novel method to ensure delivery of the specified IVF on each individual tooth in the clinic will also be tested. This comprehensive study will pave the way for clinical trials using this technology. Further, associated biomechanics and biological studies will elucidate the mechanism behind IVF based CDTM, which will further advance the field as well as methods for applying this technology.

用于翻译基于动物的振动力研究的剂量分析用于加速正畸牙齿 运动前往诊所 抽象的 控制的差齿运动（CDTM）是指移动牙齿的能力更快，或 为了最大程度地减少牙齿的移动为固定（即，在保留阶段，锚固牙齿或牙齿）。 CDTM在常见的正畸治疗中高度期望 突出和空间闭合。成功的CDTM大大缩短了治疗时间，并减少了常见的侧面 - 诸如根部吸收和锚固损失之类的影响。研究表明，间歇性振动力（IVF） 叠加在正畸力上会加速牙齿运动。此外，在没有正畸力的情况下 IVF增强牙槽骨的骨矿物质密度。但是，目前几乎没有证据可以促进 最佳选择刺激水平。此外，缺乏对目标牙齿刺激水平的控制 不可避免地会导致结果不一致。拟议工作的总体目标是启用 通过从成功的动物研究过渡到临床应用，CDTM在诊所中。目标的目标 拟议的项目包括：1）确定加速正畸牙齿运动的最佳IVF刺激水平 在大鼠以及相关的副作用中； 2）验证IVF对骨骼增强的影响，导致牙齿 稳定； 3）确定可用于扩展刺激升高的阈值 像狗和人类。我们假设：（H1）有一个最佳的IVF水平，可以加速运动 无副作用的目标牙齿； （H2）相同的IVF可以强化牙齿周围的骨头 正畸力并减少保留期间的复发； （H3）牙周韧带（PDL）的压力可以是 用作有效扩大刺激水平从大鼠到较大物种的阈值 加速牙齿运动。这些假设将通过三个特定目标进行检验。目标1：确定 在正畸负载系统上叠加的IVF（OLIVF）刺激的最佳水平，该系统加速了牙齿 大鼠模型（H1）的运动和相关的生物反应。目标2：确定OLIVF的影响 在没有正畸力的牙齿上（H2）。目标3：对包括狗在内的较大物种的刺激水平扩展 和人类，通过将PDL的压力归一化，并验证狗理论（H3）。 PDL应力阈值 在这项拟议的研究中，将用作将IVF从大鼠缩放到狗的标准，并注视缩放 在以后的研究中归纳人类。因此，一种新的方法，确保每个人都交付指定的IVF 诊所中的牙齿也将进行测试。这项全面的研究将为临床试验铺平道路 技术。此外，相关的生物力学和生物学研究将阐明IVF背后的机制 基于CDTM，它将进一步推进该领域以及应用此技术的方法。