Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

将基于动物的振动力研究加速正畸牙齿移动的剂量分析转化为临床

• 批准号: 10596536
• 负责人: JIE CHEN
• 金额: $ 45.4万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596536
• 关键词: Acceleration; Ally; Animals; Biological; Biomechanics; Bone Density; Canis familiaris; Clinic; Clinical; Clinical Research; Clinical Trials; Devices; Dose; Elements; Ensure; Frequencies; Future; Goals; Human; Iatrogenesis; Individual; Investigation; Litigation; Mature Bone; Mediating; Methods; Modeling; Movement; Orthodontic; Orthodontic Appliances; Outcome; Patients; Pattern; Periodontal Ligament; Phase; Positioning Attribute; Rattus; Reaction; Relapse; Reporting; Root Resorption; Specific qualifier value; Stress; System; Technology; Testing; Time; Tooth Movement; Tooth structure; Traction; Translating; Work; alveolar bone; bone; clinical application; new technology; novel; relapse prevention; response; scale up; side effect; theories; vibration

Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic ABSTRACT Controlled Differential Tooth Movement (CDTM) refers to the ability to move teeth to be displaced faster, or to minimize the movement of teeth to be stationary (i.e., anchorage teeth or teeth during the retention phase). CDTM is highly desired in common orthodontic treatments such as canine retraction, canine impaction, molar protraction, and space closure. Successful CDTM drastically shortens treatment time and reduces common side- effects such as root resorption and anchorage loss. Studies show that an intermittent vibration force (IVF) superimposed on orthodontic force accelerates tooth movement. Further, in the absence of orthodontic force, IVF strengthens bone mineral density of the alveolar bone. However, currently there is little evidence to facilitate optimal selection of stimulation level. Furthermore, lack of control on stimulation level on the target tooth inevitably results in inconsistent reporting of outcomes. The overarching goal of the proposed work is to enable CDTM in the clinic by transitioning from successful animal studies to clinical applications. Objectives of the proposed project include: 1) identifying optimal IVF stimulation level for accelerating orthodontic tooth movement in rats as well as associated side-effects; 2) verifying effects of IVF on bone strengthening resulting in tooth stabilization; and 3) determining the threshold that can be used to scale stimulation level up for larger species like dogs and humans. We hypothesize that: (H1) there is an optimal level of IVF that accelerates movement of targeted teeth without side-effects; (H2) the same IVF can strengthen the bone surrounding the tooth without orthodontic force and reduce relapse during retention; and (H3) stress in the periodontal ligament (PDL) can be used as the threshold to effectively scale up the stimulation level from rats to larger species for achieving accelerated tooth movement. These hypotheses will be tested through three specific aims. Aim 1: Determine the optimal level of IVF (OLIVF) stimulation superimposed on an orthodontic load system that accelerates tooth movement in a rat model (H1) and the associated biological responses. Aim 2: Determine the effects of OLIVF on the tooth without orthodontic force (H2). Aim 3: Scale up stimulation level for larger species including dogs and humans, by normalizing to stress in the PDL, and validate the theory on dogs (H3). A PDL stress threshold will be used as the criterion for scaling up IVF from rats to dogs in this proposed study, with an eye toward scaling up to humans in future studies. Thus, a novel method to ensure delivery of the specified IVF on each individual tooth in the clinic will also be tested. This comprehensive study will pave the way for clinical trials using this technology. Further, associated biomechanics and biological studies will elucidate the mechanism behind IVF based CDTM, which will further advance the field as well as methods for applying this technology.

基于动物的振动力研究加速正畸牙齿转化的剂量分析 前往诊所 抽象的 受控差异牙齿移动（CDTM）是指移动牙齿更快移位的能力，或 尽量减少静止牙齿的移动（即支抗牙齿或固位阶段的牙齿）。 CDTM 在常见的正畸治疗中非常受欢迎，例如尖牙内收、尖牙阻生、磨牙 延长和空间闭合。成功的 CDTM 大大缩短了治疗时间并减少了常见副作用 影响如牙根吸收和锚固损失。研究表明间歇振动力 (IVF) 叠加在正畸力上可加速牙齿移动。此外，在没有正畸力的情况下， 体外受精可增强牙槽骨的骨矿物质密度。然而，目前几乎没有证据表明可以促进 刺激水平的最佳选择。此外，缺乏对目标牙齿刺激水平的控制 不可避免地导致结果报告不一致。拟议工作的总体目标是使 CDTM 在临床中的应用，从成功的动物研究过渡到临床应用。目标 拟议的项目包括：1）确定加速正畸牙齿移动的最佳 IVF 刺激水平 在大鼠中以及相关的副作用； 2) 验证 IVF 对骨骼强化和牙齿生长的影响 稳定； 3) 确定可用于扩大较大物种刺激水平的阈值 就像狗和人类一样。我们假设：（H1）存在加速 IVF 运动的最佳水平。 有针对性的牙齿，无副作用； (H2) 相同的 IVF 可以强化牙齿周围的骨骼，而无需 正畸力并减少固位期间的复发； (H3) 牙周膜应力 (PDL) 可以是 用作阈值，有效地将刺激水平从大鼠扩大到更大的物种，以实现 加速牙齿移动。这些假设将通过三个具体目标进行检验。目标 1：确定 最佳水平的 IVF (OLIVF) 刺激叠加在正畸负载系统上，加速牙齿生长 大鼠模型中的运动（H1）和相关的生物反应。目标 2：确定 OLIVF 的效果 在没有正畸力的牙齿上（H2）。目标 3：扩大对包括狗在内的大型物种的刺激水平 和人类，通过 PDL 中的压力正常化，并在狗身上验证该理论 (H3)。 PDL 压力阈值 在这项拟议的研究中，将被用作将体外受精从大鼠扩大到狗的标准，着眼于扩大规模 取决于人类在未来的研究中。因此，一种确保每个人都能接受指定 IVF 的新方法 牙齿也会在诊所接受测试。这项综合研究将为使用该技术的临床试验铺平道路 技术。此外，相关的生物力学和生物学研究将阐明 IVF 背后的机制 基于 CDTM，这将进一步推进该领域以及应用该技术的方法。