Non-operative therapeutic approach for cancer in deep abdomen by the control using ultrasonic frequency cepstrum analysis and infra-red light analysis.

超声频率倒谱分析和红外光分析控制的深腹癌症非手术治疗方法。

• 批准号: 62870029
• 负责人: KAMADA Takenobu
• 金额: $ 14.08万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62870029/
• 关键词: Ultrasonic frequency-cepstrum analysis; Infrared light analysis; non-operative therapy for cancer; htperthermia; fiber bundle; ケプストラム解析; 肝癌

The aim of this investigation is to develope a non-operative, hyperthermia system for cancer treatment with continuous monitoring of cancer tissue by ultrasonic frequency-cepstrum analysis and infra-red light analysis. For this purpose, we introduced a radio-frequency type hyperthermia system and monitored the tissue temperature by Cu-constantan thermocouple. Simultaneously, we developed (1) an infra-red monitoring system for tissue hemodynamics and tissue oxygenation using a thin optical fiber and 2) a ultrasonic frequency-cepstrum system for morphological analysis of hepatic lobules. The former enabled to estimate the oxygenation level of local tissue, thereby determining the local functional change following hyperthermic reaction. The latter was applied to chronic liver diseases including hepatocellular carcinoma, and afforded non-invasive, objective informations as to pathological changes of microstructures of hepatic tissue: cancer tissue showed a wide histogram of average distance of scatters in the liver, thereby differenciating the cancerous region from cirrhosis. Hyperthermia induced an increase of blood flow in normal tissue rather homogeneously, but quite heterogenously in the imjured tissues. Oxygenation level also changed heterogenously in the latter tissue, which resulted in tissue derangement and could be monitored by ultrasonic frequency-cepstrum analyzing system. The combination of the instrument for advanced cancers.

本研究的目的是开发一种非手术，热疗系统的癌症治疗与连续监测癌组织的超声频率倒谱分析和红外光分析。为此，我们介绍了一种射频式热疗系统，并通过铜-康铜热电偶监测组织温度。同时，我们开发了（1）红外监测系统的组织血流动力学和组织氧合使用薄光纤和2）超声频率倒频谱系统的肝小叶的形态分析。前者能够估计局部组织的氧合水平，从而确定热反应后局部功能的变化。后者应用于包括肝细胞癌在内的慢性肝病，提供了肝组织微结构病理变化的无创、客观信息：癌组织在肝内散点平均距离的直方图较宽，从而将癌区与肝硬化区区分开来。高温引起的正常组织中的血流量增加相当均匀，但在受损组织中相当不均匀。后一种组织的氧合水平也发生了不均匀的变化，导致组织紊乱，可以通过超声频率倒谱分析系统进行监测。该仪器的组合用于晚期癌症。

项目成果

Kawano,S.;Sato,N.;Eguchi,H.;Tsuji,S.;Matsumura,T.;Kamada,T.: Biomedical and social aspects of alcohol and alcohlism.367-370 (1988)

Kawano,S.；Sato,N.；Eguchi,H.；Tsuji,S.；Matsumura,T.；Kamada,T.：酒精和酗酒的生物医学和社会方面。367-370 (1988)

Sato, N.; Kawano, S.; Fukuda, M.; Kamada, T.: "The effects of a prostaglandin E1 analogue, misoprostol, on gastric mucosal blood volume index and homogloibn oxygen saturation in humans" J. Gastroenterology and Hepatology. 2. 499-505 (1987)

坐在。;

Inoue, A.; Sato, N.; Matumura, T.; Eguchi, H.; Takei, Y.; Kawano, S.; Kamada, T.: "Regional hepatic tissue oxygenation and bile flow in rats" Cytoprotection and Cytobiology. 4. 83-88 (1987)

井上，A.；

Sato N;Tsuji S;Kawano S;Matsumura T; Kamada T.: Microcirculation-an update. 2. 437-440 (1987)

佐藤 N;辻 S;河野 S;松村 T;

Kawano, S.; Sato, N.; Eguchi, H.; Tsuji, S.; Matsumura, T.; Kamada, T.: "Visible and infrared spectrophotometry of tissue and organ" Biomedical and Social Aspects of Alcohol and Alcoholism (Elsevier Science Publishers, Tokyo). 367-370 (1988)

河野，S.；