Non-operative therapeutic approach for cancer in deep abdomen by the control using ultrasonic frequency cepstrum analysis and infra-red light analysis.

本研究的目的是开发一种用于癌症治疗的非手术热疗系统，通过超声波频率倒谱分析和红外光分析连续监测癌症组织。为此，我们引入了射频式热疗系统，并通过铜康铜热电偶监测组织温度。同时，我们开发了（1）使用细光纤用于组织血流动力学和组织氧合的红外监测系统，以及 2）用于肝小叶形态分析的超声频率倒谱系统。前者能够估计局部组织的氧合水平，从而确定高热反应后的局部功能变化。后者应用于包括肝细胞癌在内的慢性肝病，提供有关肝组织微观结构病理变化的非侵入性客观信息：癌组织显示肝脏内散点平均距离的宽直方图，从而区分癌变区域和肝硬化。高温引起正常组织中血流量的增加相当均匀，但在受伤组织中却相当不均匀。后者组织中的氧合水平也发生不均匀变化，导致组织紊乱，并且可以通过超声频率倒谱分析系统进行监测。该仪器组合用于治疗晚期癌症。

The aim of this investigation is to develope a non-operative, hyperthermia system for cancer treatment with continuous monitoring of cancer tissue by ultrasonic frequency-cepstrum analysis and infra-red light analysis. For this purpose, we introduced a radio-frequency type hyperthermia system and monitored the tissue temperature by Cu-constantan thermocouple. Simultaneously, we developed (1) an infra-red monitoring system for tissue hemodynamics and tissue oxygenation using a thin optical fiber and 2) a ultrasonic frequency-cepstrum system for morphological analysis of hepatic lobules. The former enabled to estimate the oxygenation level of local tissue, thereby determining the local functional change following hyperthermic reaction. The latter was applied to chronic liver diseases including hepatocellular carcinoma, and afforded non-invasive, objective informations as to pathological changes of microstructures of hepatic tissue: cancer tissue showed a wide histogram of average distance of scatters in the liver, thereby differenciating the cancerous region from cirrhosis. Hyperthermia induced an increase of blood flow in normal tissue rather homogeneously, but quite heterogenously in the imjured tissues. Oxygenation level also changed heterogenously in the latter tissue, which resulted in tissue derangement and could be monitored by ultrasonic frequency-cepstrum analyzing system. The combination of the instrument for advanced cancers.