Non-operative therapeutic approach for cancer in deep abdomen by the control using ultrasonic frequency cepstrum analysis and infra-red light analysis.

本研究的目的是开发一种非手术、热疗系统，用于癌症治疗，通过超声频率倒频谱分析和红外线分析对癌症组织进行连续监测。为此，我们引入了一种射频热疗系统，并通过Cu-constantan热电偶监测组织温度。同时，我们开发了(1)使用薄光纤的组织血流动力学和组织氧合的红外监测系统和(2)用于肝小叶形态分析的超声频率倒频谱系统。前者可以估计局部组织的氧合水平，从而确定高温反应后局部功能的变化。后者应用于包括肝细胞癌在内的慢性肝病，为肝组织显微结构的病理变化提供了非侵入性、客观的信息：癌组织在肝脏中散点的平均距离呈宽直方图，从而将癌区与肝硬化区区分开来。热疗诱导正常组织的血流量增加相当均匀，而损伤组织的血流量增加则相当不均匀。后一种组织的氧合水平也发生了异质性变化，导致组织紊乱，可以通过超声频率倒谱分析系统进行监测。结合仪器治疗晚期癌症。

The aim of this investigation is to develope a non-operative, hyperthermia system for cancer treatment with continuous monitoring of cancer tissue by ultrasonic frequency-cepstrum analysis and infra-red light analysis. For this purpose, we introduced a radio-frequency type hyperthermia system and monitored the tissue temperature by Cu-constantan thermocouple. Simultaneously, we developed (1) an infra-red monitoring system for tissue hemodynamics and tissue oxygenation using a thin optical fiber and 2) a ultrasonic frequency-cepstrum system for morphological analysis of hepatic lobules. The former enabled to estimate the oxygenation level of local tissue, thereby determining the local functional change following hyperthermic reaction. The latter was applied to chronic liver diseases including hepatocellular carcinoma, and afforded non-invasive, objective informations as to pathological changes of microstructures of hepatic tissue: cancer tissue showed a wide histogram of average distance of scatters in the liver, thereby differenciating the cancerous region from cirrhosis. Hyperthermia induced an increase of blood flow in normal tissue rather homogeneously, but quite heterogenously in the imjured tissues. Oxygenation level also changed heterogenously in the latter tissue, which resulted in tissue derangement and could be monitored by ultrasonic frequency-cepstrum analyzing system. The combination of the instrument for advanced cancers.