An insturment to determine and degree of inflammation in the anterior chamber, quantitatively and objectively

定量、客观地确定前房炎症程度的仪器

• 批准号: 62870070
• 负责人: MASUDA Kanjiro
• 金额: $ 15.87万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62870070/
• 关键词: Cell-flare meter; Blood-barrier; Blood-aqueous barrier; anti-inflammatory drug; 手術術語炎症; エンドトキシン; 炎症定量測定; 術後炎症; 非ステロイド点眼液

We deved a new instrument to measure the concentration of protein and unmber of cells in the anterior chamber of the eye, quantitatively and objectively. There was a close positive relationship between the photon count and the concentration of protein or the number of cells in vitro.In the animal experiments, we could obtain the same results as these in vitro. From the human experiments, we got the results that there is an increase the protein in the anterior chamber as age increases and that there is a definite diurnal varition in the protein concentration. By using this insturment, we can judge the time course of the uveitis in patients, the effects of the drugs, the postoperative inflammation and the effects of anti-inflammatory drugs.

我们研制了一种新的仪器，可定量、客观地测量眼前房内蛋白质浓度和细胞数。在体外实验中，光子数与蛋白质浓度和细胞数均呈正相关，在动物实验中也可获得与体外实验相同的结果。从人体实验中，我们得到的结果是，随着年龄的增长，前房中的蛋白质含量增加，并有一定的昼夜变化。通过该仪器可以判断患者葡萄膜炎的时程、药物的疗效、术后炎症反应及抗炎药物的疗效。

项目成果

Tetsuro, Oshika; Makoro, Araie; Kanjiro, Masuda: "Diurnal Variation of Aqueous Flare in Normal Human Eyes Measured wtih Laser-Cell Meter" Acta Societatis Ophthalmologicae Japonicae. 92. 1196-1201 (1988)

铁郎，大鹿；

Tetsuro OSHIKA;Makoto ARAIE;Kanjiro MASUDA: Japanese Journal of Ophthalmology. 32. 143-150 (1988)

Tetsuro OSHIKA；Makoto ARAIE；Kanjiro MASUDA：日本眼科杂志。

大鹿哲郎,増田貫次郎: 臨床眼科. 43. 177-180 (1989)

Tetsuro Oshika，Kanjiro Masuda：临床眼科。43。177-180（1989）

増田寛次郎: 日本眼科紀要. 39. 1113-1117 (1988)

Kanjiro Masuda：日本眼科通报 39. 1113-1117 (1988)

近藤正己,天野史郎,増田貫次郎: 臨床眼科. 42. 781-784 (1988)

Masami Kondo、Shiro Amano、Kanjiro Masuda：临床眼科学 42. 781-784 (1988)。