Biochemistry of the ocular irritation

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After the paracentesis or photocoagulation on the iris, the eye showed irritative responses such as miosis, increased protein concentration in aqueous humor. These irritative responses were mainly mediated by prostaglandins <E_2> and <F_2> <alpha> . Indomethacin prevented these phenomena.Intracameral injections of PGs mimiced the ocular irritative responses. Leukotriens might played a minor role in these processes.Substance P and Vasoactive intestinal polypeptide (VIP) were also detected in aqueous humor after the stimuli. Intracameral injection of SP caused strong miosis, but no increase in protein concentration. VIP injection into the anterior chamber increased protein concentration but caused no miosis.These facts suggested that the irritative responses might be mediated mainly by PGs and partly by SP and VIP.Indomethacin pretreatment prevented the irritative responses caused by cataract surgery in human eyes.