Biochemistry of the ocular irritation

眼刺激的生物化学

• 批准号: 60480388
• 负责人: MASUDA Kanjiro
• 金额: $ 4.1万
• 依托单位: Tokyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480388/
• 关键词: Prostaglandin; leukotrien; irritative ocular responses; substance P; VIP; 眼刺激症状

After the paracentesis or photocoagulation on the iris, the eye showed irritative responses such as miosis, increased protein concentration in aqueous humor. These irritative responses were mainly mediated by prostaglandins <E_2> and <F_2> <alpha> . Indomethacin prevented these phenomena.Intracameral injections of PGs mimiced the ocular irritative responses. Leukotriens might played a minor role in these processes.Substance P and Vasoactive intestinal polypeptide (VIP) were also detected in aqueous humor after the stimuli. Intracameral injection of SP caused strong miosis, but no increase in protein concentration. VIP injection into the anterior chamber increased protein concentration but caused no miosis.These facts suggested that the irritative responses might be mediated mainly by PGs and partly by SP and VIP.Indomethacin pretreatment prevented the irritative responses caused by cataract surgery in human eyes.

虹膜穿刺或光凝后，眼睛表现出瞳孔缩小、房水蛋白浓度升高等刺激反应。这些刺激反应主要由前列腺素<E_2>和<F_2> < α >介导。吲哚美辛可以防止这些现象。眼内注射pg模拟眼部刺激反应。白蛋白可能在这些过程中起次要作用。刺激后房水中也检测到P物质和血管活性肠多肽（VIP）。鸡眼内注射SP可引起较强的细胞缩小，但未引起蛋白浓度升高。前房注射VIP使蛋白浓度升高，但未引起细胞缩小。这些事实表明，刺激反应可能主要由pg介导，部分由SP和VIP介导。吲哚美辛预处理可预防白内障手术引起的人眼刺激反应。

项目成果

カプリオリ.ヨセフ,増田寛次郎,ヨハン.シュターンシャンツ著,マービン.シアーズ,ターカネン.アーティ編: "眼の手術における薬物" ラビン・プレス, 592 (1985)

Joseph Caprioli、Kanjiro Masuda、Johann Sternschanz、Marvin Sears、Tarkanen Artie（编辑）：“眼科手术中的药物”Rabin Press，592 (1985)

増田寛次郎著,徳田久弥編集: 眼科における薬の使用法. 139-161 (1985)

增田宽次郎撰写，德田久哉编辑：如何在眼科使用药物 139-161 (1985)。

岡本平,倉崎茂,石井幸久,増田寛次郎: 日本眼科紀要. 37. 1271-1278 (1986)

Taira Okamoto、Shigeru Kurasaki、Yukihisa Ishii、Kanjiro Masuda：日本眼科通报 37. 1271-1278 (1986)。

岡本平,松村譲,倉崎茂,石井幸久,増田寛次郎: 日本眼科紀要. 37. 180-185 (1986)

Taira Okamoto、Yuzuru Matsumura、Shigeru Kurasaki、Yukihisa Ishii、Kanjiro Masuda：日本眼科通报 37. 180-185 (1986)。

Taira Okamoto, Yuzuru Matsumura, Shigeru Kurasaki, Yukihisa Ishii and Kanjiro Masuda: "Flurbiprofen Ophthalmic Solution-Basic Experiments" The Folia Ophthalmologica Japonica. 37. 180-185 (1986)

Taira Okamoto、Yuzuru Matsumura、Shigeru Kurasaki、Yukihisa Ishii 和 Kanjiro Masuda：“氟比洛芬滴眼液 - 基础实验”The Folia Ophthalmologica Japonica。