权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

血液ー眼柵の研究

血眼栅栏研究

基本信息

批准号：
63440065
负责人：
MASUDA Kanjiro
金额：
$ 18.43万
依托单位：
General University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

The blood-ocular barrier performs a very important function in keeping eyes normal. Once in is disrupted vision-threatening pathology will develop. However, there has been no objective, quantitative and noninvasive way to determine the state of this barrier. In this investigation we observed the following results.1) The development of the laser flare-cell meter, an instrument with easy maneuverability, enabled us to determine the degree of flare and the number of cells, in the anterior chamber. These are the most important parameters to show the disruption of the blood-aqueous barrier. By using the laser flare-cell meter we could assess the physiological and pathological conditions of the blood-aqueous barrier.2) After intra-ocular surgery, we can observe high degree of flare and a large number of calls in the anterior chamber. The most frequent type of surgery for ophthalmologists is that of cataract extraction. By using the laser flare-cell meter we can judge which cataract surgical technique is the best, which anti-inflammatory drugs are the bet to reduce the postoperative inflammation, and which type of intra-ocular lens is the best.3) Endogenous uveitis could be observed in the anterior chamber of patients by using the laser flare-cell meter to obtain quantitative information. These data helped us use anti-inflammatory drugs rationally and made it possible to predict oncoming attacks in Behcet's and Vogt-Koyanagi-Harada disease.4) Hemorrhagic glaucoma increases the level of flare in cases of diabetic retinopathy and retinal vein occlusion.This laser flare-cell meter can reveal the beginning of rubeosis of iris resulting in hemorrhagic glaucoma.We could prevent this disease condition by treating patients in the early stages of the disease.

血-眼屏障在维持眼睛正常方面起着非常重要的作用。一旦被破坏，就会发展出威胁视力的病理。然而，目前还没有客观、定量和非侵入性的方法来确定这一屏障的状态。在本次研究中，我们观察到了以下结果：1)激光耀斑细胞仪的研制使我们能够确定前房的耀斑程度和细胞数量，该仪器具有易操作性。这些是显示血-房水屏障破坏的最重要的参数。2)眼内手术后，可观察到高度的闪光和前房大量的叫声。眼科医生最常做的手术是白内障摘除手术。通过使用激光散斑细胞仪可以判断哪种白内障手术方法最好，哪种抗炎药物更好地减轻术后炎症，哪种类型的人工晶状体最好。3)利用激光散斑细胞仪获得定量信息，可以观察到患者前房内的内源性葡萄膜炎。这些数据帮助我们合理使用抗炎药物，使我们能够预测白塞病和Vogt-Koyanagi-Harada病的来袭。4)出血性青光眼增加了糖尿病视网膜病变和视网膜静脉阻塞患者的闪光水平。这种激光闪光细胞仪可以揭示虹膜红斑的开始，导致出血性青光眼。我们可以通过对患者进行早期治疗来预防这种疾病。