Chronical electrical stimulation for treatment of aged voice
慢性电刺激治疗老年嗓音
基本信息
- 批准号:409543779
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2018
- 资助国家:德国
- 起止时间:2017-12-31 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Age related weakening of the voice has long been neglected, but gained consideration lately, as vocal endurance is essential in many professions up to higher ages. The noticeable glottal gap and vocal fold (VF) bowing are the most prominent video-laryngoscopic findings in these patients and are mainly related to the atrophy of the thyroarytenoid muscle (TAM). For the proposed project, we hypothesize that functional electrical stimulation (FES) of the recurrent laryngeal nerves (RLN) will counteract age related laryngeal muscular atrophy. Based on previous work we hypothesize in particular that FES will lead to an increase of muscle fiber diameters, and an upregulation of molecular markers of muscle hypertrophy with no subsequent changes of the fibre type distribution. An increase of muscle fibre diameters will lead to an increase of the volume of the TAM, thus diminishing the glottal gap. We furthermore hypothesize that the changes elicited by FES will lead to significantly improved phonatory characteristics being observable in improved laryngeal dynamics and acoustics as assessed by the phonatory ex-vivo experiments.FES will be done for the first time bilaterally in an aged in-vivo ovine model. During surgery, stimulation electrodes will be placed near the common trunk of the RLN before entering the larynx and will be connected to a laryngeal pacing implant located at the neck. Predesigned training patterns will be automatically delivered and repeated every second day for eleven weeks, once the implant was programmed, thus no further anaesthesia or sedation will be necessary during the training, or follow-up endoscopies. After euthanasia outcome parameters will be evaluated in a multi-modal based setting, reaching from the cellular/molecular (immuno-histology, gene expression, signalling pathways) to the anatomical level (micro CT scans/3D-reconstructions) and will comprise important functional testing (phonatory ex-vivo experiments).The proposed project will be pursued in a joint action combining the expertise of Assoc. Prof. Dr. Markus Gugatschka (Medical University Graz, Austria) and Prof. Dr. Michael Döllinger (Friedrich-Alexander University Erlangen-Nürnberg, Germany). While the group of Assoc. Prof. Gugatschka will perform all tasks related to implantation surgery and follow-up, as well as assessing the outcome parameters of FES on a molecular/cellular and anatomical level, the group of Prof. Döllinger will perform ex-vivo phonatory experiments. Combining molecular, histological, anatomical and functional outcome parameters in such a model is a crucial, yet an unmet goal and will create an unprecedented set of data. By direct stimulation of the RLN we preserve the natural anatomy and integrity of the larynx resp. the VF and can counteract directly the underlying reason of presbyphonia. Before going into clinical trials, experiments of this kind in large animal models are indispensable.
与年龄有关的声音减弱长期以来一直被忽视,但最近得到了考虑,因为声音耐力在许多职业中至关重要,直到更高的年龄。明显的声门间隙和声带(VF)弯曲是这些患者最突出的视频喉镜检查结果,主要与甲杓肌(TAM)萎缩有关。对于拟议的项目,我们假设,功能性电刺激(FES)的喉返神经(RLN)将抵消年龄相关的喉肌萎缩。基于以前的工作,我们假设特别是FES将导致肌纤维直径的增加,以及肌肉肥大的分子标志物的上调,而纤维类型分布没有随后的变化。肌纤维直径的增加将导致TAM体积的增加,从而减小声门间隙。我们进一步假设,FES引起的变化将导致显着改善发声特性被观察到改善喉动力学和声学评估的发声体外ex-vivo experiments.FES将首次在一个老年人在体内绵羊模型双侧。在手术过程中,刺激电极将在进入喉部之前放置在RLN的共同干附近,并将连接到位于颈部的喉部起搏植入物。一旦植入物被编程,预先设计的训练模式将自动提供并每隔一天重复一次,持续11周,因此在训练或随访内窥镜检查期间不需要进一步的麻醉或镇静。安乐死后,将在基于多模式的环境中评价结局参数,从细胞/分子水平(免疫组织学,基因表达,信号通路)到解剖学水平(微型CT扫描/3D重建),并将包括重要的功能测试(发声离体实验)。拟议的项目将在一个联合行动中进行,该行动将结合副教授Markus Gugatschka博士的专业知识。(奥地利格拉兹医科大学)和Michael Döllinger教授(德国埃尔朗根-纽伦堡弗里德里希-亚历山大大学)。Gugatschka副教授小组将执行与植入手术和随访相关的所有任务,以及在分子/细胞和解剖学水平上评估FES的结果参数,而Döllinger教授小组将执行离体发声实验。在这样一个模型中结合分子、组织学、解剖学和功能结果参数是一个至关重要的,但尚未实现的目标,并将创建一组前所未有的数据。通过直接刺激喉返神经,我们保留了喉的自然解剖结构和完整性。能直接对抗老视的潜在原因。在进入临床试验之前,在大型动物模型中进行此类实验是必不可少的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Professor Dr.-Ing. Michael Döllinger其他文献
Professor Dr.-Ing. Michael Döllinger的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Professor Dr.-Ing. Michael Döllinger', 18)}}的其他基金
Numerical computation of the human voice source
人声源的数值计算
- 批准号:
391215328 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Research Grants
Biomechanical analysis methods of soft tissue in the larynx
喉部软组织的生物力学分析方法
- 批准号:
323404598 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Research Grants
Induced asymmetries in an excised larynx model: Impact of mucus characteristics on dynamics and acoustics
切除喉模型中引起的不对称:粘液特性对动力学和声学的影响
- 批准号:
281313362 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Research Grants
Kinesthetic and auditory feedback during phonation and articulation
发声和发音过程中的动觉和听觉反馈
- 批准号:
230251342 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Research Grants
Auditory-motor control analysis of voice production in hearing impaired speakers by means of Machine Learning
通过机器学习对听力受损者发声的听觉运动控制进行分析
- 批准号:
511281818 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Grants
Deep learning networks for quantitative evaluation of organic voice disorders and their treatment
用于定量评估器质性嗓音障碍及其治疗的深度学习网络
- 批准号:
468206600 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Grants
Objective analysis of functional based hoarseness by clinical high-speed endoscopy
临床高速内镜客观分析功能性声音嘶哑
- 批准号:
323308998 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Grants
Endoscopic laser-based 3D imaging for clinical real-time analysis of the human larynx
基于内窥镜激光的 3D 成像,用于人体喉部的临床实时分析
- 批准号:
448240908 - 财政年份:
- 资助金额:
-- - 项目类别:
New Instrumentation for Research
相似国自然基金
脊髓电刺激活化Na(V)1.1阳性GABA神经元持续缓解癌痛
- 批准号:82371223
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
基于电阻层析成象和电磁流量计融合的两相流检测研究
- 批准号:60772044
- 批准年份:2007
- 资助金额:8.0 万元
- 项目类别:面上项目
相似海外基金
Realizing Human Brain Stimulation of Deep Regions Based on Novel Personalized Electrical Computational Modelling
基于新型个性化电计算模型实现人脑深部刺激
- 批准号:
23K25176 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (B)
CAREER: Modulating endothelial cell function using targeted electrical stimulation
职业:使用靶向电刺激调节内皮细胞功能
- 批准号:
2338949 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Continuing Grant
ERI: Mechanistic understanding of neural stem cell paracrine activity and extracellular vesicle secretion directed by wireless electrical stimulation
ERI:无线电刺激引导的神经干细胞旁分泌活性和细胞外囊泡分泌的机制理解
- 批准号:
2301908 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Standard Grant
Functional evaluation of spatio-temporal characteristics of electrical retinal stimulation by temporal interference
时间干扰视网膜电刺激时空特征的功能评估
- 批准号:
23K09025 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Effects of skeletal muscle electrical stimulation on hyperglycemia-induced arterial stiffness
骨骼肌电刺激对高血糖引起的动脉僵硬度的影响
- 批准号:
23K10586 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (C)
Joint Impedance Training Method Based on EMG-controlled Exoskeleton Robot and Electrical Stimulation
基于肌电控制的外骨骼机器人和电刺激的关节阻抗训练方法
- 批准号:
23H03242 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Scientific Research (B)
Functional hand and wrist motion control using functional electrical stimulation electrode arrays
使用功能性电刺激电极阵列进行功能性手部和腕部运动控制
- 批准号:
2891052 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Studentship
Cognitively engaging walking exercise and neuromodulation to enhance brain function in older adults
认知性步行锻炼和神经调节可增强老年人的大脑功能
- 批准号:
10635832 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Charge-Based Brain Modeling Engine with Boundary Element Fast Multipole Method
采用边界元快速多极子法的基于电荷的脑建模引擎
- 批准号:
10735946 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Development of a Piezoelectric Intramedullary Nail for Enhanced Fracture Healing
开发用于增强骨折愈合的压电髓内钉
- 批准号:
10759862 - 财政年份:2023
- 资助金额:
-- - 项目类别: