Induced asymmetries in an excised larynx model: Impact of mucus characteristics on dynamics and acoustics

切除喉模型中引起的不对称：粘液特性对动力学和声学的影响

• 批准号: 281313362
• 负责人: Professor Dr.-Ing. Michael Döllinger
• 金额: --
• 依托单位: Abteilung für Phoniatrie und Pädaudiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/281313362?language=en
• 关键词: Induced; asymmetries; excised; larynx; model

Voice disorders do not only result from anatomical tissue alterations in the vocal folds. The phonation process is a complex interaction between airflow, laryngeal tissue structures, mucosal surface layer (i.e. mucus) and the resulting acoustic outcome. The functionality of this fluid-structure-acoustic interaction can be disturbed by left-right asymmetries in the dynamical behavior and insufficient closure of the vocal folds during oscillation; i.e. the phonation process is disturbed and the voice quality is reduced. This project is based on the hypothesis that the coupling between the contributory factors of phonation is highly dependent and influenced by the mucus layer that covers the vocal folds and represents the natural boundary layer between airflow and tissue. Up to date, this interrelation has been neglected in phonation studies. The identification and quantification of a compensatory mechanism of mucus on dynamics and hence the acoustics would be highly desirable in guiding voice quality for non-invasive treatment.The central objective of this project is the investigation of laryngeal mucus and its role in the cause-and-effect chain of the phonation process. Hence, synthetic mucus will be created with characteristic viscoelastic properties in the range of natural human mucus samples. The influence of the synthetic mucus samples towards the phonation process will be tested in the computer controlled experimental setup which was developed in the previous project phase. This setup enables variable adjustment of the laryngeal boundary conditions (i.e. induced asymmetry and glottal gap) and simultaneous multimodal measurements (i.e. high-speed videoendoscopy, flow, subglottal pressure, acoustic signal). This will allow a thorough quantification of all the contributing factors and reveal the causal interrelations in phonation. The ex vivo studies will be performed using excised porcine larynges received from the local slaughterhouse.

声音障碍不仅仅是由声带的解剖组织改变引起的。发声过程是气流、喉组织结构、粘膜表层（即粘液）和由此产生的声学结果之间复杂的相互作用。这种流体-结构-声学相互作用的功能可能受到动力学行为的左右不对称和振荡期间声带闭合不足的干扰；即，发声过程受到干扰，声音质量降低。这个项目是基于这样一个假设，即发声因素之间的耦合高度依赖并受覆盖在声带上的黏液层的影响，黏液层代表着气流和组织之间的自然边界层。到目前为止，这种相互关系在语音研究中被忽视了。黏液对动力学和声学的补偿机制的识别和量化对于指导语音质量进行非侵入性治疗是非常可取的。本项目的中心目标是喉部粘液的调查及其在发声过程的因果链中的作用。因此，合成黏液将在天然人类黏液样品的范围内具有典型的粘弹性。合成黏液样品对发声过程的影响将在计算机控制的实验装置中进行测试，该实验装置是在上一个项目阶段开发的。这种设置可以对喉边界条件（即诱导不对称和声门间隙）进行可变调整，并同时进行多模态测量（即高速视频内窥镜、流量、声门下压力、声信号）。这将允许对所有促成因素进行彻底的量化，并揭示发音中的因果关系。离体研究将使用从当地屠宰场获得的切除的猪喉进行。

项目成果

Human Laryngeal Mucus from the Vocal Folds: Rheological Characterization by Particle Tracking Microrheology and Oscillatory Shear Rheology

声带中的人类喉部粘液：通过粒子追踪微流变学和振荡剪切流变学进行流变表征

• DOI: 10.3390/app11073011
• 发表时间: 2021
• 期刊: Applied sciences (Basel, Switzerland)
• 作者: G. Peters;O. Wendler;D. Böhringer;S. K. Gostian A.-O.and Müller;H. Canziani;N. Hesse;M. Semmler;D. A. Berry;S. Kniesburges;W. Peukert;M. Döllinger
• 通讯作者: M. Döllinger