Addressing the interrelation between immunosenescence and post-myocardial infarction healing processes

解决免疫衰老与心肌梗塞后愈合过程之间的相互关系

• 批准号: 411619907
• 负责人: Privatdozent Dr. Gustavo C. Ramos, Ph.D.
• 金额: --
• 依托单位: Deutsches Zentrum für Herzinsuffizienz Würzburg
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/411619907?language=en
• 关键词: Addressing; interrelation; between; immunosenescence; post

The prevalence of cardiovascular diseases (CVD) increases dramatically with age. Nevertheless, most of the basic research in Cardiology has been conducted on young healthy animals which may not necessarily reflect the situation observed in the clinic. Emerging evidences show that the both the heart, and the immune system undergo dramatic changes with aging, and there is an unmet need to understand how those alterations ultimately affect the outcomes of cardiovascular diseases in elderly subjects. Over the past few years, we have observed that T-cells foster the post-myocardial infarction (MI) repair process in young mice, but fuel detrimental myocardial inflammation in aged animals. Next, plan to combine these variables (aging, MI, and T-cells) into a unified picture to attain greater translational relevance. Thus, we herein propose to combine refined experimental approaches with biomaterial available from well-characterised MI-patients to address the interrelation between immunosenescence and the post-myocardial infarction healing process.

心血管疾病（CVD）的患病率随着年龄的增长而急剧增加。然而，心脏病学的大部分基础研究都是在年轻健康的动物身上进行的，这可能不一定反映临床观察到的情况。新出现的证据表明，心脏和免疫系统都随着年龄的增长而发生巨大变化，并且需要了解这些变化最终如何影响老年受试者心血管疾病的结果。在过去的几年里，我们已经观察到T细胞促进了年轻小鼠心肌梗死（MI）后的修复过程，但在老年动物中助长了有害的心肌炎症。接下来，计划将联合收割机这些变量（老化、MI和T细胞）组合成一个统一的画面，以获得更大的翻译相关性。因此，我们在此建议将联合收割机改进的实验方法与来自特征良好的MI患者的生物材料相结合，以解决免疫衰老和心肌梗死后愈合过程之间的相互关系。